Lysophosphatidic Acid Mediates Fibrosis In Injured Joints By Regulating Collagen Type I Biosynthesis

摘要

ObjectiveArticular cartilage is a highly specialized tissue which forms the surfaces in synovial joints. Full-thickness cartilage defects caused by trauma or microfracture surgery heal via the formation of fibrotic tissue characterized by a high content of collagen I (COL I) and subsequent poor mechanical properties. The goal of this study is to investigate the molecular mechanisms underlying fibrosis after joint injury.