A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of healthcare workers

摘要

The medical treatment of cancer with antineoplastic drugs is routine, but careful biomonitoring for these powerful drugs in individual healthcare worker exposure is necessary to ensure that engineering controls and exposure intervention measures are effective. This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tools for monitoring of healthcare worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research.