A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers

摘要

Highlights ? Review of HPLC–MS/MS methods for quantitation of anticancer drugs in urine. ? Includes drugs, isomers, drug metabolites and simultaneous multi-drug determinations. ? Tabular summaries of method sample preparation, LC parameters, and MS detection modes. ? Presents comparative overview of methods, their development, and validation protocols. ? Discussion of future trends including UHPLC–MS/MS and simultaneous multi-drug methods. Abstract This review describes published high performance liquid chromatography/mass spectrometry (HPLC–MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC–MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC–MS methods are presented, as well as future trends and limitations in this area of research. ]]>