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A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

机译：I / II期安慰剂对照随机试验的重组脱氧核糖核酸酶（DNase）滴眼液用于干眼病患者

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摘要

PurposeTo determine whether DNase eye drops have the potential to reduce signs and symptoms of dry eye disease (DED).

机译：目的确定DNase滴眼液是否有潜力减轻干眼病（DED）的体征和症状。

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期刊名称 Translational Vision Science Technology
作者
Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain;
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作者单位

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年(卷),期 -1(8),3
年度 -1
页码 10
总页数 12
原文格式 PDF
正文语种
中图分类眼科学;
关键词
DNase dry eye clinical trial NETs;

机译：DNase;干眼症;临床试验;NET;

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专利

1. Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients with Dry Eye Disease: Results of a Randomized Clinical Trial [J] . Mun Christine, Tibrewal Sapna, Ahn Anna, Investigative ophthalmology & visual science . 2019,第9期

机译：重组脱氧氧核酸酶（DNase）滴眼液用于干眼症患者：随机临床试验结果
2. Influence of Perfluorohexyloctane Eye Drops on Tear Film Thickness in Patients with Mild to Moderate Dry Eye Disease: A Randomized Controlled Clinical Trial [J] . Journal of ocular pharmacology and therapeutics: The official journal of the Association for Ocular Pharmacology and Therapeutics . 2020,第3期

机译：全氟己基辛烷滴眼液对轻度至中度干眼症患者撕裂膜厚度的影响：随机对照临床试验
3. Pooling of two randomized Phase III clinical trials of ciclosporin 1 mg/mL cationic emulsion (CsA CE) as a treatment for severe keratitis in patients with dry eye disease (DED) [J] . Messmer Elisabeth, Leonardi Andrea, Amrane Mourad, Investigative ophthalmology & visual science . 2016,第12期

机译：汇集西孢菌素1mg / ml阳离子乳液（CSA Ce）的两种随机期III临床试验作为干眼症患者严重角膜炎的治疗（DED）
4. Optimizing Management of Paediatric Diarrhoeal Disease: A Pilot, Factorial, Randomized, Placebo-Controlled Trial of Rapid Enteric Diagnostics and Probiotics [C] . David Goldfarb, Jeffrey Pernica, Andrew Steenhoff, International Molecular Medicine Tri-Conference. . 2016

机译：优化儿科腹泻病管理：快速肠诊断和益生菌的试点，阶乘，随机，安慰剂对照试验
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Efficacy and safety of 0.05 cyclosporine ophthalmic emulsion in treatment of Chinese patients with moderate to severe dry eye disease: A 12-week multicenter randomized double-masked placebo-controlled phase III clinical study [O] . Di Chen, Shunhua Zhang, Ailing Bian, -1

机译：0.05％环孢素眼用乳剂治疗中度至重度干眼病的疗效和安全性：一项为期12周的多中心随机双盲安慰剂对照的III期临床研究
7. Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome [O] . 2015

机译：多中心，随机，双层，安慰剂对照临床结果的干燥眼综合征患者中Visomitin滴眼液的疗效和安全性研究

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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