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Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial

机译：树突状细胞疫苗和IL-2对肾细胞癌或乳腺癌患者的联合治疗：I / II期试验的结果

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BackgroundTen cancer patients (Six renal cell carcinoma and four breast cancer patients) were treated in a phase I/II study with a vaccine composed of autologous dendritic cells (DCs) and IL-2 to evaluate the DC vaccine-related toxicity and antigen-specific immune alteration.

机译：背景在I / II期研究中，对10名癌症患者（六名肾细胞癌和四名乳腺癌患者）进行了治疗，该疫苗由自体树突状细胞（DC）和IL-2组成，以评估DC疫苗相关的毒性和抗原特异性免疫改变。

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期刊名称 Journal of Translational Medicine
作者
Soyoung Baek; Choung-Soo Kim; Sung-Bae Kim; Yong-man Kim; Seog-Woon Kwon; YongMan Kim; HyunSoo Kim; Hyunah Lee;
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作者单位

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年(卷),期 2011(9),-1
年度 2011
页码 178
总页数 10
原文格式 PDF
正文语种
中图分类医学史;
关键词
Dendritic cell vaccine Renal cell carcinoma Breast cancer Phase I/II trial Immune response;

机译：树突状细胞疫苗;肾细胞癌;乳腺癌;I / II期试验;免疫应答;

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专利

1. Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial [J] . Soyoung Baek, Choung-Soo Kim, Sung-Bae Kim, Journal of Translational Medicine . 2011,第1期

机译：树突状细胞疫苗和IL-2对肾细胞癌或乳腺癌患者的联合治疗：I / II期试验的结果
2. A randomized phase II trial comparing two different sequence combinations of autologous vaccine and human recombinant interferon gamma and human recombinant interferon alpha2B therapy in patients with metastatic renal cell carcinoma: clinical outcome [J] . Schwaab T, Heaney JA, Schned AR, The Journal of Urology . 2000,第4期

机译：一项随机II期试验，比较了转移性肾细胞癌患者中自体疫苗与人重组干扰素γ和人重组干扰素α2B治疗的两种不同序列组合：临床结果
3. Phase-I study of Innacell γδ?, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma [J] . BennounaJ., BompasE., NeidhardtE.M., Cancer immunology, immunotherapy : . 2008,第11期

机译：在转移性肾细胞癌患者中，Innacellγδα（一种高度自体γ9δ2T淋巴细胞结合IL-2的自体细胞治疗产品）的I期研究
4. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-Dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant [C] . Leona A. Holmberg, Katherine A. Guthrie, Brenda M. Sandmaier Chemical glycobiology . -1

机译：大剂量化学疗法和自体干细胞拯救治疗的Theratope（STn-KLH）癌症疫苗治疗的乳腺癌和卵巢癌患者的临床结果：自体移植后的Theratope（STn-KLH）癌症疫苗
5. Potentiation of the immune response with aluminum-containing adjuvants: I. Distribution of adsorbed antigen in mono-valent and combination vaccines; II. Role of antigen adsorption in antigen internalization by dendritic cells. [D] . Morefield, Garry Lee, Jr. 2003

机译：含铝佐剂增强免疫应答：I.单价和组合疫苗中吸附抗原的分布；二。抗原吸附在树突状细胞的抗原内在化中的作用。
6. Randomized-controlled phase II trial of salvage chemotherapy after immunization with a TP53-transfected dendritic cell-based vaccine (Ad.p53-DC) in patients with recurrent small cell lung cancer [O] . Alberto A. Chiappori, Charles C. Williams, Jhanelle E. Gray, -1

机译：TP53转染的基于树突状细胞的疫苗（Ad.p53-DC）免疫后复发小细胞肺癌患者的挽救性化疗II期随机对照研究
7. Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial [O] . Soyoung Baek, Choung-Soo Kim, Sung-Bae Kim, 2011

机译：树突状细胞疫苗和IL-2对肾细胞癌或乳腺癌患者的联合治疗：I / II期试验的结果
8. Phase II Study of a HER-2/neu (HER2) Intracellular Domain (ICD) Peptide- Based Vaccine Administered to Stage IIIB and IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab Monotherapy; Annual rept. 27 Apr 2007-26 Apr 2008 [R] . Disis, M. L. 2008

机译：对接受曲妥珠单抗单一疗法的IIIB和IV期HER2阳性乳腺癌患者施用HER-2 / neu（HER2）细胞内结构域（ICD）基于肽的疫苗的II期研究;年度报告。 2007年4月27日至2008年4月26日

Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial

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