MANUFACTURING OF MULTI-DOSE INJECTION READY DENDRITIC CELL VACCINES, COMBINATION THERAPIES FOR BLOCKING HER2 AND HER3, AND ESTROGEN RECEPTOR POSITIVE HER2 BREAST RECEPTOR POSITIVE HER2 BREAST CANCER THERAPY

摘要

The present embodiments relate to an FDA-approved injectable multi-dose antigen pulsed dendritic cell (DC) vaccine. In one embodiment, the activated antigen-loaded DC vaccine comprises an initial immunizing dose and multiple “booster” doses. Also provided is a method of blocking both HER-2 and HER-3 as a treatment in causing permanent tumor senescence in HER-2 expressing breast cancers. Also provided is combination anti-estrogen therapy and anti-HER2 dendritic call vaccination for ER^pos/HER2^pos DCIS breast cancer patients.