Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo

摘要

Aim:To formulate proliposomes with a polyphase dispersed system composed of soybean phospholipids, cholesterol, isopropyl myristate and sodium cholate to improve the oral bioavailability of dehydrosilymarin, an oxidized form of herbal drug silymarin.