Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression and is associated with poor prognosis in basal-like breast cancers

摘要

IntroductionBasal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg.