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Unusual phenotype and function of an expanded subpopulation of T cells in patients with haemopoietic disorders.

机译:造血障碍患者中异常的表型和扩大的T细胞亚群的功能。

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摘要

We have studied two patients, one with red cell aplasia and the other with neutropenia. Both showed lymphocytosis. In both cases, 90-100% of E rosetting cells were T cells as defined by the monoclonal antibodies UCHT1 and OKT3. The majority of these cells also carried the OKT8 suppressor/cytotoxic marker and were HLA-DR- and Fc gamma R-positive. In spite of the similarity of this phenotype to that reported for suppressor cells, these cells failed to suppress pokeweed mitogen-induced polyclonal Ig synthesis. Cells from both patients also failed to respond significantly to Con A and PHA. They were, however, unable to suppress the Con A responses of normal donors although cells from one patient were able to suppress completely a normal PHA response. These results demonstrate the existence of a genuine subset of T cells with Fc gamma receptors but suggest that not all such cells have typical suppressor function.
机译:我们研究了两名患者,一名患有红细胞发育不全,另一名患有中性粒细胞减少。两者均显示淋巴细胞增多。在两种情况下,如单克隆抗体UCHT1和OKT3所定义,E玫瑰花结细胞中有90-100%是T细胞。这些细胞中的大多数还带有OKT8抑制剂/细胞毒性标记,并且是HLA-DR和FcγR阳性。尽管该表型与抑制细胞的表型相似,但这些细胞未能抑制商陆有丝分裂原诱导的多克隆Ig合成。两名患者的细胞对Con A和PHA均无明显反应。然而,尽管来自一名患者的细胞能够完全抑制正常的PHA反应,但它们无法抑制正常供体的Con A反应。这些结果证明存在具有Fcγ受体的T细胞的真正子集,但是表明并非所有此类细胞都具有典型的抑制功能。

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