Prohibitin 1 Deficiency Causes Impairment of Lipid Metabolism and the Disruption Is Deteriorated by Excessive Palmitic Acids in Hepatocytes (P08-106-19)

摘要

ObjectivesNon-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid in hepatocytes. In spite of the growing number of NAFLD patients with the increased prevalence of obesity, the pathogenesis of NAFLD remains to be fully elucidated. Prohibitin1 (Phb1) is an evolutionarily conserved protein, which is expressed predominantly on the inner mitochondrial membrane. Several studies have provided evidences that the Phb1 plays a crucial role not only in proliferation of hepatocytes, but also in lipid metabolism in adipocytes. Since the liver is the major site for lipid metabolism, this study was aimed to understand the lipid metabolism regulated by Phb1 in hepatocytes.