The Tiotropium Safety and Performance in Respimat® Trial (TIOSPIR®) a large scale randomized controlled parallel-group trial-design and rationale

摘要

BackgroundTiotropium bromide is an effective therapy for COPD patients. Comparing across programs tiotropium Respimat® Soft Mist™ inhaler was at least as efficacious as tiotropium HandiHaler®, however, concerns have been raised about tiotropium’s safety when given via Respimat®.