Wnt activity guides facial branchiomotor neuron migration and involves the PCP pathway and JNK and ROCK kinases

摘要

BackgroundWnt proteins play roles in many biological processes, including axon guidance and cell migration. In the mammalian hindbrain, facial branchiomotor (FBM) neurons undergo a striking rostral to caudal migration, yet little is known of the underlying molecular mechanisms. In this study, we investigated a possible role of Wnts and the planar cell polarity (PCP) pathway in this process.