Bioactive Constituents from the Aerial Parts of Pluchea indica Less

摘要

Four new thiophenes, (3′′R)-pluthiophenol (>1), (3′′R)-pluthiophenol-4′′-acetate (>2), 3′′-ethoxy-(3′′S)-pluthiophenol (>3), 3′′-ethoxy-(3′′S)-pluthiophenol-4′′-acetate (>4), together with twenty-five known compounds were obtained from the 70% ethanol-water extract of the aerial parts of Pluchea indica Less. Their structures were elucidated by spectroscopic methods. Among the known isolates, compounds >7, >8, >11, >14, >15, >18, >20, >23, >25–>27 were isolated from Asteraceae family firstly, while compounds >6, >9, >10, >12, >13, >16, >19, >21, >28 were isolated from Pluchea genus for the first time. Meanwhile, compounds >1, >2, >10, >13, >18, >23 displayed significant inhibitory activities on LPS-induced NO production at 40 µM from RAW 264.7 macrophages, while compounds >3, >4, >26–>29 possessed moderate inhibitory effects.