Analgesic Activity of Infusion of Beluntas Radix (Pluchea indica (L.)) on the Male Mice

摘要

Objectives: The study aims to determine the analgesic activity of beluntas radix infusion. Method: The research used 25 of male mice. The mice were divided into five groups, which are negative control, positive control, and three testing groups (in different doses). Fifteen minutes after infusion of beluntas radix per oral, the mice were given the acetic acid 0.7% i.p. The cumulative writhe was calculated in every 5 minutes for one hour and was counted for the protection and the effectivity percentage. Results and Discussions: Beluntas radix infusion of doses 9.75 mg/20 g, 19.5 mg/20 g and 29.25 mg/20 g of body weight decreased the writhing responses significantly (p<0.05) compared with the control. Each doses gave the protection percentage 55.8% 64.2% and 77.5% and the effectivity percentage 113.4% 130.5% and 157.5%. Conclusion: Analgesic activity of beluntas radix infusion is influenced by dose level. Test dose III (29.25 mg / 20 g BW of mice) has the best activity.