INVENTION OF NOVEL SEMI SYNTHETIC DERIVATIVES FROM PITCII (THIOPHEN DERIVATIVE) ISOLATED FROM TISSUE CULTURED MEDICINAL PLANT PLUCHEA INDICA (L.) LESS

摘要

The naturally occurring molecule PITC-II of Pluchea indica showed impressive bio activity. Research indicates lipohilic characteristic may improve bio activity. We designed and synthesize few derivatives( Acetyl and Benzyl semi-synthetic compounds) from PITC II and found effective against malarial parasites. Both the compounds are more potent and safe than the parent compound PITC II.