THIOPHENE DERIVATIVES FROM THE AERIAL PART OF PLUCHEA INDICA

摘要

Chemical investigation on the aerial part of Pluchea indica resulted in the isolation of two new thiophene derivatives,2-(4-hydroxy-3-methoxybut-l-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene(1)and 2-(4-O-beta-glucopyranosyl-3-hydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene(2)along with three known thiophene derivatives 2-(3,4-dihydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene(3),2-(3-acetoxy-4-hydroxybut-1-yn-1-yl)-5-(penta-1,3-diyn-1-yl)thiophene(4)and 2-(prop-1-yn-1-yl)-5-(6-acetoxy-5-hydroxyhexa-1,3-diyn-1-yl)thiophene(5).The structures of 1 and 2 were determined on the bases of extensive spectroscopic analysis,including 1D and 2D NMR data.Antimicrobial activities of compounds 1-5 were tested.