Clinical efficacy and safety of rituximab in lupus nephritis

机译：利妥昔单抗治疗狼疮性肾炎的临床疗效和安全性

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摘要

BackgroundLong-term treatment programs with low toxicity represent a therapeutic challenge in lupus nephritis (LN). Although a therapeutic benefit of rituximab (RTX) has been reported in LN patients who have failed conventional treatment, the results are controversial. We aimed to assess the clinical efficacy and safety of RTX as a new immunosuppressive medicine in the treatment of LN with a meta-analysis.

机译：背景低毒性的长期治疗方案代表了狼疮性肾炎（LN）的治疗挑战。尽管在常规治疗失败的LN患者中已报道了利妥昔单抗（RTX）的治疗益处，但结果尚存争议。我们旨在通过荟萃分析评估RTX作为治疗LN的新型免疫抑制剂的临床疗效和安全性。

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期刊名称 Drug Design Development and Therapy
作者
Zhiqing Zhong; Hongyan Li; Hongzhen Zhong; Tianbiao Zhou;
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作者单位

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年(卷),期 2019(13),-1
年度 2019
页码 845–856
总页数 12
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
systemic lupus erythematosus lupus nephritis rituximab efficacy safety meta-analysis;

机译：系统性红斑狼疮;狼疮肾炎;利妥昔单抗;疗效;安全性;荟萃分析;

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专利

1. Clinical efficacy and safety of rituximab in lupus nephritis [J] . Zhiqing Zhong, Hongyan Li, Hongzhen Zhong, Drug Design, Development and Therapy . 2019,第InaProgress期

机译：利妥昔单抗治疗狼疮性肾炎的临床疗效和安全性
2. Efficacy and safety of rituximab in Japanese patients with systemic lupus erythematosus and lupus nephritis who are refractory to conventional therapy [J] . Tanaka Yoshiya, Takeuchi Tsutomu, Miyasaka Nobuyuki, Modern rheumatology . 2016,第1期

机译：利妥昔单抗在日本系统性红斑狼疮和狼疮肾炎患者中的常规治疗无效
3. Efficacy and safety of rituximab in comparison with common induction therapies in pediatric active lupus nephritis [J] . Basu Biswanath, Roy Birendranath, Babu Binu George Pediatric nephrology: journal of the International Pediatric Nephrology Association . 2017,第6期

机译：Rituximab与儿科活性狼疮性常见疗法相比的疗效和安全性
4. IMMEDIATE AND LONG-TERM EFFICACY AND SAFETY OF PHOTODYNAMIC THERAPY WITH PHOTOLON? (FOTOLON?) - A SEVEN-YEAR CLINICAL EXPERIENCE [C] . Yuri P. Istomin, Michael A. Kaplan, Siarhei. V. Shliakhtsin, World congress of the International Photodynamic Association . 2009

机译：使用光子进行光动力疗法的近期和长期疗效以及安全性？（FOTOLON？）-七年临床经验
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. Efficacy and safety of rituximab in Japanese patients with systemic lupus erythematosus and lupus nephritis who are refractory to conventional therapy [O] . Yoshiya Tanaka, Tsutomu Takeuchi, Nobuyuki Miyasaka, -1

机译：利妥昔单抗在日本系统性红斑狼疮和狼疮肾炎患者中的常规治疗无效
7. Efficacy and safety of rituximab in Japanese patients with systemic lupus erythematosus and lupus nephritis who are refractory to conventional therapy [O] . Tanaka Yoshiya, Takeuchi Tsutomu, Miyasaka Nobuyuki, 2016

机译：利妥昔单抗在日本系统性红斑狼疮和狼疮肾炎患者中的常规治疗无效

Clinical efficacy and safety of rituximab in lupus nephritis

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