Novel Benzofurans with 99mTc Complexes as Probes for Imaging Cerebral β-Amyloid Plaques

摘要

Two novel benzofuran derivatives coupled with ^99mTc complexes were tested as probes for imaging cerebral β-amyloid plaques using single photon emission tomography. Although both derivatives bound to Aβ(1−42) aggregates, ^99mTc-BAT-BF showed higher affinity than ^99mTc-MAMA-BF. In sections of brain tissue from an animal model of AD, ^99mTc-BAT-BF clearly labeled β-amyloid plaques. In biodistribution experiments using normal mice, ^99mTc-BAT-BF displayed high uptake soon after its injection and washed out from the brain rapidly, a highly desirable feature for an imaging agent. ^99mTc-BAT-BF may be a potential probe for imaging β-amyloid plaques in Alzheimer's brains.