μ‐Opioid receptor activation prevents acute hepatic inflammation and cell death

摘要

Background and aimsThe detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti‐inflammatory properties of the μ‐opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation and cell death—major determinants in the pathogenesis of liver diseases.