Note: A Functional cra Gene Is Required for Salmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

摘要

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad⁻, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad⁻ that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.