Objective To observe the dynamic changes of peripheral blood natural killer(NK)cell,complement C3,serum protein levels in patients with acute craniocerebral trauma,and to provide reference for clinical treatment. Methods 60 patients with acute craniocerebral injury in our hospital from May 2016 to January 2018 were selected as the research subjects,and they were divided into 37 cases of light-mild group and 23 cases of severe group by Glasgow Coma Scale(GCS). And 60 healthy controls were selected as control group at the same time. The blood samples of light-mild group and severe group were collected after admission in first,third,fifth,seventh day,and the positive rate of peripheral blood NK cell, complement C3 level and serum protein [serum albumin(ALB),interleukin-6(IL-6),serum c-reactive protein(CRP)]levels were detected. Results After admission in first,third,fifth and seventh day,the positive rate of NK cell of light-mild group and severe group were lower than that of control group,and severe group was lower than light-mild group(P<0.05). After admission in first day,the complement C3 level of light-mild group and severe group were lower than that of control group,the complement C3 level in third,fifth day were higher than control group,the complement C3 level in seventh day of severe group was higher than that of control group,the complement C3 level of severe group after admission in third,fifth and seventh day was higher than that of light-mild group(P<0.05). After admission in first,third,fifth,seventh day,the ALB level of light-mild group and severe group were lower than that of control group,the IL-6 and CRP levels were higher than those of control group,the ALB level of severe group after admission in first,third,fifth,seventh day was lower than that of light-mild group,the IL-6 and CRP levels were higher than light-mild group(P<0.05). Conclusion The peripheral blood NK cell,serum ALB,IL-6,CRP levels of acute craniocerebral trauma patients gradually decrease as time prolongs,and complement C3 level gradually increases. Therefore, observing the dynamic changes of NK cells, complement C3 and serum protein levels in patients'peripheral blood can provide reference for clinical prediction of acute craniocerebral injury.%目的 观察急性颅脑损伤患者外周血自然杀伤细胞(NK)、补体C3、血清蛋白水平动态变化,为临床治疗提供参考依据.方法 选取2016年5月至2018年1月急性颅脑损伤患者60例,按格拉斯哥昏迷评分法(GCS)将其分轻中型组37例、重型组23例.另选取同期体检健康者60例为对照组.患者在入院第1、3、5、7天采集血液样本,检测外周血NK细胞阳性率、补体C3水平及血清蛋白[血清白蛋白(ALB)、白介素-6(IL-6)、血清C反应蛋白(CRP)]水平.结果 轻中型组和重型组患者入院第1、3、5、7天NK细胞阳性率均低于对照组,重型组低于轻中型组,差异有统计学意义(P<0.05);轻中型组和重型组患者入院第1天补体C3水平低于对照组,第3、5天补体C3水平高于对照组,重型组第7天补体C3水平高于对照组,重型组入院第3、5、7天补体C3水平高于轻中型组,差异有统计学意义(P<0.05);轻中型组和重型组入院第1、3、5、7天ALB水平均低于对照组,IL-6、CRP水平高于对照组,重型组入院第1、3、5、7天的ALB水平均低于轻中型组,IL-6、CRP水平均高于轻中型组,差异有统计学意义(P<0.05).结论 急性颅脑损伤患者随着时间延长,其外周血NK细胞水平及血清ALB、IL-6、CRP水平不断降低,补体C3水平不断增加,故观察患者外周血NK细胞、补体C3及血清蛋白水平的动态变化,能为临床预测急性颅脑损伤程度提供参考依据.
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