肝癌患者手术部位感染病原菌和影响因素分析

摘要

Objective To summarize the surgical site infection pathogenic bacteria distribution and influential factors of cancer of the liver in order to provide reference basis for targeted prevention and intervention measures. Methods Three hundred and fourteen cancer patients of the liver who were treated in the general surgery department in our hospital from March 2008 to March 2013 were selected as observation objects,the clinical data of cancer patients were collected by the self-made general data questionnaire,they were analysed by descriptive statistics and binary classification logistic regression analysis to find out the surgical site infection pathogenic bacteria distribution and influential factors of cancer of the liver. Results The surgical site infection rate of cancer of the liver was 16.88%(53/314),the most common infection of pathogenic bacteria was mainly gram-negative bacteria (67.67%). Multiple logistic regression analysis showed that venerable age≥65 (OR=5.040, P=0.000),malnutrition(OR=18.322,P=0.000),surgical duration>5 hours (OR=12.372,P=0.000) and history of diabetes (OR=16.141,P=0.000) had risk factors of cancer of the liver. Conclusion The surgical site infection rate of cancer of the liver is high,the infection of pathogenic bacteria was mainly gram-negative bacteria,it is affected by various factors.%目的：探究并分析肝癌患者手术部位感染病原菌分布和影响因素，为采取针对性的预防干预措施提供参考依据。方法2008年3月至2013年3月收治的314例肝癌患者，采用自编问卷收集肝癌患者的临床资料，运用SPSS19.0统计软件包对收集的资料进行描述性统计和二分类Logistic回归分析找出肝癌患者手术部位感染病原菌和影响因素。结果肝癌患者手术部位感染发生率为16.88%（53/314），以革兰阴性菌为主（占67.67%）。多因素Logistic回归分析示高龄≥65岁（OR=5.040，P=0.000）、营养不良（OR=18.322，P=0.000）、手术持续时间>5h（OR=12.372，P=0.000）和糖尿病史（OR=16.141，P=0.000）是肝癌患者手术部位感染的危险因素。结论肝癌患者手术部位感染发生率较高，以革兰阴性菌为主，其发生受多方面因素影响。