中药镇痛机理研究概述

摘要

目的：对中药的镇痛机理研究进行综述。方法：查阅近5年的国内外文献，对中药在中枢和外周神经系统中调节β-内啡肽（β-EP）、5-羟色胺（5-HT）、前列腺素 E2（PGE2）、一氧化氮（NO）等的作用进行归纳、分析、总结。结果：通过中枢神经系统发挥镇痛作用的途径主要包括增加阿片肽类的含量、抑制第二信使神经递质 NO 的释放、降低脑组织中 PGE2的含量以及提高中枢5-HT 的含量等；通过外周神经系统发挥镇痛作用的途径主要包括减少外周致痛物质、减轻局部致痛物质的堆积、增加外周内源镇痛物质的释放以及调节原癌基因（c-fos）等。结论：应进一步加强对中药镇痛机制的研究，为镇痛中药的进一步开发利用提供参考。%Objective:To review the analgesic mechanism of Chinese medicine.Methods:The regulation of beta-endorphin(β-EP),5-hydroxytryptamine (5-HT),prostaglandin2 (PGE2 ),nitric oxide (NO)and so on in central nervous system and peripheral nervous system were analyzed and concluded based on the recent five years’studies from home and abroad.Results:Analgesic effect played through the central nervous system was effected by increasing the content of endogenous analgesic substances like opi-oid peptide,cutting down the second messenger of neurotransmitter like NO,reducing the content of PGE2 in brain tissue and rai-sing the content of the central 5-HT;analgesic effect played through the peripheral nervous system was effected by reducing the pe-ripheral algogenic substance and inducing pain caused by the secretion of pain,inducing the accumulation of part algogenic sub-stance,increasing the releasing peripheral endogenous analgesia material and adjusting the c-fos gene.Conclusion:Basic research should be conducted to do further study.