摘要:目的:探讨清胰汤对急性胰腺炎患者血清白介素(IL)-6、10和肿瘤坏死因子(TNF)-α水平的影响及疗效观察.方法:94例急性胰腺炎患者按随机数字表法分为清胰汤组和对照组,2组均给予西医对症治疗.清胰汤组加用清胰汤100 mL自胃管灌注,夹管2h,每日1次;观察2组患者治疗前和治疗7d后血清IL-6、IL-10、TNF-α和血淀粉酶水平的变化并比较其临床疗效.结果:治疗7d后,2组血清IL-6、TNF-α和血淀粉酶水平均明显下降,血清IL-10水平均明显上升,且清胰汤组变化幅度较对照组更明显;同时清胰汤组临床总有效率95.74%,明显优于对照组的80.85%.结论:清胰汤治疗急性胰腺炎的疗效确切,其作用与降低血清IL-6和TNF-α水平,提高血清IL-10水平,减轻急性炎症反应,从而降低血淀粉酶水平有关.%Objective:To discuss influence and curative effect observation of Qingyi Decoction on serum interleukin-6 (IL-6),interleukin-10 (IL-10) and tumor necrosis factor-or (TNF-α) levels of patients with acute pancreatitis (AP).Methods:94 cases of patients with acute pancreatitis (AP) were selected and divided into Qingyi Decoction group and control group at random.The patients in two groups were given western symptomatic treatment.The patients in Qingyi Decoction group were additionally given 100 ml Qingyi Decoction,which was poured through stomach tube,clamped for 2 hours once a day.The changes of serum IL-6,IL-10,TNF-α and AMS levels of patients in two groups before and 7 days after medical treatment were observed,and curative effect observation was carried on as well.Results:After 7 days' medical treatment,serum IL-6,TNF-α and AMS levels of patients in two groups obviously declined than before,while serum IL-10 level obviously rose than before,and the declining or rising rate in Qingyi Decoction group were much higher than those in control group.Meanwhile,total clinical efficiency of patients in Qingyi Decoction group (95.74%) was much higher than that in control group (80.85%).Conclusion:Qingyi Decoction has reliable curative effect on AP,whose mechanism of action has close effect on reducing serum IL-6 and TNF-α levels,improving serum IL-10 level,then reducing acute inflammatory reaction,AMS level of patients with AP.