西沙诺丽通便和降糖作用的药效学研究

摘要

Objective:To observe the defaecation and hypoglycemic effect of Xisha Noni.Methods:The intestine movement in nor-mal mice,and the time for the first defecation,defecation number and soil weight of constipation mouse model induced by loperam -ide hydrochloride were observed following the treatment with Xisha Noni lyophiled powder at different dose that were orally taken by the normal mice and the constipation mice in order to investigate its defaecation effect.The diabetic mouse model induced by strep-tozotocin was adopted in the experiment to observe the hypoglycemic action of Noni.Also,its effects on the blood sugar and glucose tolerance in normal rats were studied.Results:Xisha Noni can remarkably increase the small intestine propulsive proportion in the normal mice,shorten the time for the first defecation in constipation mice models induced by loperamide hydrochloride,and increase the defecation number and their soil weight.In addition,Xisha Noni can remarkably decrease blood glucose level in the diabetic mice model induced by streptozotocin,but it had no significant effects on blood glucose and glucose tolerance in normal rats.Con-clusion:Xisha Noni lyophiled powder appears to possess the effects of both defaecation and hypoglycemic.%目的:观察西沙诺丽的通便和降糖的药效.方法:ICR小鼠,灌胃给予不同剂量的西沙诺丽冻干粉,观察对正常小鼠小肠运动和对盐酸洛哌丁胺导致便秘模型小鼠首粒排便时间、排便粒数及粪便重量的影响.观察西沙诺丽冻干粉对链脲佐菌素导致小鼠糖尿病模型和对正常大鼠血糖和糖耐量的影响.结果:西沙诺丽能够显著增加正常小鼠小肠推进率,可明显缩短盐酸洛哌丁胺导致便秘模型动物首次排便时间,能够显著增加模型动物排便次数和动物粪便重量.西沙诺丽能够显著降低链脲佐菌素导致糖尿病模型血糖水平,但是对正常大鼠血糖和糖耐量的没有明显影响.结论:西沙诺丽冻干粉具有通便和降糖作用.