新疆锡伯族、蒙古族高血压患者血清CyPA水平变化及其临床意义

摘要

Objective To investigate the correlation of cyclophilin A (CyPA) level in patients with essential hyperten⁃sion(EH)in Xinjiang Xibo and Mongolia populations and to investigate its clinical significance. Methods EH patients (n=76) and healthy control subjects (n=62) were selected from Xinjiang Xibo populations. On the other hand, EH patients (n=66)and healthy control subjects (n=57) were selected from Xinjiang Mongolia populations. Serum cyclophilin A was measured using enzyme-linked immunosorbent assay(ELISA). Parameters such as age, body mass index(BMI), waist, waist hip ratio, blood pressure were measured in each group. The correlation of cyclophilin A with each parameter was analyzed. Results The levels of serum cyclophilin A in EH patients in Xinjiang Xibo and Xinjiang Mongolia populations were significantly high⁃er than those in their corresponding healthy control groups(P<0.05). Serum cyclophilin A in patients with essential hyperten⁃sion(EH)in Xinjiang Mongolia population was signifantly higher than that in EH patients from Xinjiang Xibo population (P<0.05). There was a positive correlation between serum cyclophilin A level and occurance of EH in both Xinjiang Xibo and Xinjiang Mongolia populations. Conclusion The serum cyclophilin A is significant higher in EH patients in both Xinji⁃ang Xibo and Xinjiang Mongolia populations so it is positively correlated with occurance of EH (P<0.05). Cyclophilin A lev⁃el is a risk factor of essential hypertension in both Xinjiang Xibo and Xinjiang Mongolia populations.%目的：观察新疆锡伯族、蒙古族原发性高血压（EH）患者血清亲环素A（CyPA）水平并探讨其临床意义。方法选取锡伯族EH患者76例和健康对照者62例，蒙古族EH患者66例和健康对照者57例。采用酶联免疫吸附法（ELISA）测定血清CyPA，检测各组的年龄、体质量指数（BMI）、腰围、腰臀比、血压等各项指标，并分析血清CyPA与各指标的相关性。结果新疆锡伯族、蒙古族EH组血清CyPA水平均显著高于健康对照组（P＜0.05）；蒙古族EH组血清CyPA水平显著高于锡伯族EH组（P＜0.05）；高血压患者血清CyPA水平与血压呈正相关（P＜0.05）。结论新疆锡伯族、蒙古族EH患者血清CyPA明显升高，并与血压存在一定的相关性。血清CyPA升高是新疆锡伯族、蒙古族EH的危险因素。