新疆哈萨克族高血压患者血浆妊娠相关蛋白A水平变化及临床意义

摘要

Objective To explore the plasma pregnancy-associated plasma protein A (PAPP-A) level in the Kazakhs patients with essential hypertension(EH) and relationship between plasma PAPP-A level and blood pressure,blood glucose,blood lipids.Methods Eighty Kazaks patients with EH were analyzed as EH group and 30 healthy subjects served as control group.The EH group was allocated to group 1 ( n = 15), group 2( n = 30),group 3( n = 35)by the grade of blood pressure.The plasma PAPP-A was detected by ELISA.Results PAPP-A level in EH group was significantly higher than that in control group,the grade 1 group(4.97±0.80) mg/L,the grade 2 group(5.99±0.86) mg/L,the grade 3 group(6.54±0.94) mg/L vs control group(3.90±0.64) mg/L( P ＜0.01).Compared with grade 1 group, the concentration of PAPP-A in grade 2 group was markedly increased ( P ＜0.01) ,and the level of PAPP-A in grade 3 group was significantly higher than that in grade 2 ( P ＜ 0.01).In EH group, PAPP-A was positively correlated with SBP,DBP,TC( rs =0.540,0.442,0.296, P ＜0.05) ,but PAPP-A correlated with none in control( p ＞0.05).Multiple regression analysis showed that SBP and TC were independent factors to affect the PAPP-A level in EH group,none was independent factors to affect the plasma PAPP-A level in control group.Conclusion The plasma PAPP-A level is increased in Kazaks patients with EH,and there is correlation beween PAPP-A and blood pressure.%目的 探讨新疆哈萨克族(哈族)原发性高血压(EH)患者妊娠相关蛋白A(PAPP-A)水平及其与血压、血脂、血糖的关系.方法 选择新疆哈族EH患者80例(EH组),哈族健康人群30例(对照组).EH组根据血压水平分为:EH 1级15例,EH 2级30例,EH 3级35例.采用酶联免疫吸附法测定血浆PAPP-A水平.结果 哈族各级EH血浆PAPP-A水平显著高于对照组,EH 1级(4.97±0.80)mg/L、EH 2级(5.99±0.86)mg/L、EH 3级(6.54±0.94)mg/L VS对照组(3.90±0.64)mg/L(P=0.540、0.442、0.296,P0.05).多元回归分析显示:在哈族 EH 组中,SBP和TC是影响PAPP-A的独立危险因素;对照组中,上述各指标均不是影响血浆PAPP-A水平的独立因素.结论 哈族 EH 患者血浆PAPP-A水平升高并与血压之间存在一定的相关性.