中期因子在涎腺腺样囊性癌组织中的表达及意义

摘要

Objective To study the expression of midkine(MK) in salivary adenoid cystic carcinoma(SACC) and its relationship with perineural invasion(PNI).Methods Immunohistochemistry staining(SP method) for MK was performed on 35 SACC and 20 normal salivary gland tissues(NSG).Then, the correlation between the expression of MK and PNI was analyzed.Results In SACC, MK was highly expressed and the positive rate was 82.9%(29/35)while it was lowly expressed and the positive rate was 10.0%(2/20)in NSG, which showed significant difference (P<0.01).There was no relationship between the expression of MK and age, sex, pathologic types (P>0.05).However, there was significant difference between PNI cases and non-PNI cases(P<0.05).Conclusions MK may be associated with generation of SACC, and its overexpression may be contributed to the perineural invasion in SACC patients.%目的 探讨中期因子(midkine,MK)在涎腺腺样囊性癌组织中的表达及其与发生嗜神经侵袭的关系.方法 采用免疫组织化学SP法检测35例涎腺腺样囊性癌组织和20例正常涎腺组织中MK蛋白的表达情况,并分析其与嗜神经侵袭的关系.结果 MK在涎腺腺样囊性癌组织中高表达,阳性表达率为82.9%(29/35),在正常涎腺组织中低表达,阳性表达率为10.0%(2/20),二者间差异有统计学意义(P<0.01);MK的表达与患者的年龄、性别以及病理分型无关(P>0.05);与肿瘤是否发生嗜神经侵袭有关(P<0.05).结论 MK蛋白可能参与涎腺腺样囊性癌的发生,其表达水平的升高可能与涎腺腺样囊性癌发生嗜神经侵袭有关.