目的 探讨β-catenin和c-myc在结直肠肿瘤中的意义.方法 用免疫组织化学技术检测非肿瘤结直肠组织、结直肠腺瘤组织和结直肠腺癌组织中β-catenin及c-myc.结果 β-catenin在非肿瘤结直肠组织、结直肠腺瘤组织和结直肠腺癌组织中异住异常表达率分别为8.0%、73.9%、96.2%,3组之间差异有统计学意义(P<0.05).非肿瘤结直肠组织、结直肠腺瘤组织和结直肠腺癌组织中c-myc表达的阳性率分别为4.0%、43.5%和76.9%,3组之间差异有统计学意义(P<0.05).结论 β-catenin异常表达及c-myc过度表达与结直肠肿瘤的发生有关,β-catenin异常表达可能与腺瘤的恶性转化易感性和结直肠腺癌的恶性行为有关,c-myc过度表达可能与结直肠肿瘤恶性化有关.%Objective To investigate the significance of β-catenin and c-myc in colorectal neoplasms. Methods The β-catertin and c-myc proteins were examined by immunohistochemistry in nomal colorectal tissue, colorectal adenoma and colorec-tal malignant adenoma. Results The cytoplasmic and nuclear β-catenin expression rates in non-tumor colorectal tissue,colorec-tal adenorna tissue and colorectal malignant adenoma tissue were 8.0%, 73.9% and 96.2% respectively. The cytoplasmic and nuclear β-catenin expression rates in colorectal adenoma tissue and colorectal malignant adenoma tissue were significantly higher than that of non-tumor colorectal tissue (P <0.05). The cytoplasmic and nuclear β-catenin expression rate in colorectal malig-nant adenoma was significantly higher than that of colorectal adenoma (P<0.05). The positive expression rates of c-myc in non-tumor colorectal tissue, colorectal adenoma tissue and colorectal malignant adenoma tissue were 4.0% ,43.5% and 76.9% re-spectively. The positive expression rates of c-myc in colorectal adenoma tissue and eolorectal malignant adenoma tissue were sig-nificantly higher than that of non-tumor colorectal tissue (P<0.05). The positive expression rates of c-myc in colorectal malignant adenoma was significantly higher than that of colorectal adenoma (P<0.05). Conclusion The cytoplasmic and nuclear β-catenin expression and the overexpression of c-myc may play a pivotal role in carcinogenesis and progression of eoloreetal carcinoma.
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