不同时机静注帕瑞昔布钠对妇科腔镜手术全麻苏醒期躁动的影响

摘要

目的：观察不同时机静注帕瑞昔布钠对妇科腔镜手术全麻苏醒期躁动的影响。方法60例在全麻下择期行妇科腔镜手术的患者,ASA I~II级,随机均分为帕瑞昔布钠I组( A组)、帕瑞昔布钠II组( B组)。 A、B组分别在手术前30min、手术结束前30min静脉注射帕瑞昔布钠40mg,观察患者术后即刻(T0)、5 min(T1)、10min(T2)、20min(T3)血压心率变化以及T2-T0的变化量、术后躁动和疼痛等情况。结果两组患者血压、心率在T2时均较其它时间点有明显升高,差异有统计学意义(P<0．05)；A组患者T2-T0的变化量、发生躁动情况和术后疼痛评分明显低于B组,差异有统计学意义(P<0．05)。结论帕瑞昔布钠在手术前注射对降低妇科腔镜手术全麻苏醒期躁动情况明显优于手术结束前。%Objective To investigate the effect of parecoxib sodium intravenous injection in different time on the emer-gence agitation( EA) in patients with gynecological laparoscopic surgeries. Methods Sixty patients of ASA physical status I or II, scheduled for gynecological laparoscopic surgeries under general anesthesia were randomized into two groups, parecoxib sodium group I(group A)and parecoxib sodium group II(group B). Group A were intravenously injected parecoxib sodium 30mg 30min prior to the operation and Group B received the same dose but 30min before the end of the operation. Blood pressure(BP), heart rate(HR), postoperative pain and emergence agitation were observed and recorded immediately(T0), 5min(T1), 10min(T2) and 20min(T3)after the operation. Variation of blood pressure and heart rate from T0 to T2from T0 to T2 were compared as well. Results Higher blood pressure and heart rate were observed in both of the two groups at T 2 , with statistic significance ( P <0. 05). And blood pressure and heart rate change from T0 to T2, emergence agitation and pain score in group A had an obvious improvement compared to group B(P<0. 05). Conclusion Intravenous injection of parecoxib sodium before the operation has a significantly better efficacy on decreasing emergence agitation in gynecological patients undergoing laparoscopic surgeries.