NF-кB传导通路基因多态性与子宫内膜癌的关系

摘要

Objective To investigate the relationship between genetic polymorphisms of NF-кB signaling pathway and endometrial carcinoma in patients.Methods A total of 100 patients with endometrial carcinoma (EC group) and 100healthy female individuals (control group) were voluntarily recruited.Genetic polymorphisms of NF-кB (-94ins/delATTG),TNF-α (G-308A),(iNOS,C608T) and (COX-2,T8473C) in NF-кB signaling pathway were detected by PCRRFLP technique and then comparative analysis was conducted.Results There were statistically significant differences in the frequency of occurrence of NF-кB (-94ins/delATTG) genetic polymorphism between the two groups (P ＜ 0.05).In addition,no statistically significant differences were observed in genotypes and allele frequencies at TNF-α (G-308A),iNOS(C608T) and COX-2 (T8473C) (all P ＞ 0.05).Conclusion Genetic polymorphisms of NF-кB(-94ins/delATrG) in NF-кB signaling pathway are associated with endometrial carcinoma.%目的 探讨子宫内膜癌(EC)患者NF-кB传导通路相关基因多态性与EC发生发展的关系.方法 选择EC患者100例(EC组)、健康体检者100例(对照组)为研究对象,采用PCR-RFLP技术检测两组NF-кB传导通路上的NF-кB(-94ins/delATTG)、TNF-α (G-308A)、一氧化氮合酶(iNOS,C608T)、环氧化酶-2(COX-2,T8473C)位点的基因多态性,并进行对比分析.结果 两组NF-кB (-94ins/delATTG)位点基因多态性出现频率比较有统计学差异(P＜0.05),TNF-α (G-308A)、iNOS(C608T)、COX-2(T8473C)位点基因多态性出现频率比较无统计学差异(P均＞0.05).结论 NF-кB传导通路NF-кB (-94ins/delATTG)位点的基因多态性与EC的发生发展有关.