Methods and reagents for determining sequence variants present at the FRZBlocus, which facilitate identifying individuals at risk for obesity and/orosteoporosis, are provided. In particular, methods for detecting anindividual's risk for obesity and/or osteoporosis by detecting at least onepolymorphism (e.g., at least one single nucleotide polymorphism) in the FRZBgene in a nucleic acid sample from the individual are provided. Related kits,arrays and systems are also described.
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