β受体阻滞剂对非小细胞肺癌患者放疗后生存率影响的研究

摘要

目的：探讨β受体阻滞剂对非小细胞肺癌患者生存率方面的作用。方法：收集接受根治性放疗的非小细胞肺癌患者256例。应用Kaplan‐M eier法推算服用β受体阻滞剂组患者与未服用组患者的生存率，用Log‐rank检验进行组间生存率的比较，并对服用β受体阻滞剂是否影响非小细胞肺癌患者放疗后生存率采用Cox回归模型分别进行单因素及多因素的分析。结果：服用β受体阻滞剂组患者的无远处转移生存率、无瘤生存率及总生存率均高于未服用组，且具有统计学意义。单因素与多因素Cox比例风险模型分析中均发现服用β受体阻滞剂与提高无远处转移生存率，无瘤生存率及总生存率等呈正相关性。结论：β受体阻滞剂是改善非小细胞肺癌患者根治性放疗疗效的独立预后因素，可提高非小细胞肺癌患者放疗后生存率。%Objective:To find out the role of beta‐blockers to the survival outcomes of the patients with non‐small‐cell lung cancer treated with definitive radiation therapy .Methods :Collect the clinical data of 256 patients with non‐small‐cell lung cancer (NSCLC) who received definitive radio therapy .A Cox proportional hazard model was utilized to determine the association between beta‐blockers intake and distant metastasis‐free survival (DMFS) , disease‐free survival (DFS) ,and overall survival (OS) .Results:Patients taking beta‐blockers had improved DMFS ,DFS ,and OS ,compared with patients not taking beta‐blockers .In univariate analysis and multivariate analysis , beta‐blockers intake was associated with a significantly better DMFS ,DFS ,and OS .Conclusions :Beta‐blockers use is associated with improved DMFS ,DFS ,and OS in the patients with non‐small‐cell lung cancer treated with defini‐tive radiation therapy .