类风湿关节炎合并肺间质病变相关因素临床分析

摘要

Objective:To analyze the clinical and laboratory indexes of patients with rheumatoid arthritis(RA)complicated with interstitial lung disease(ILD).Methods:Two hundred and iffty-six patients with RA were divided into a RA group(187 cases) and a RA-ILD group(69 cases)according to the results of high-resolution CT of the patients,and the General information,laboratory data and Disease evaluation of the patients in the two groups were compared.Results:Compared with the RA group,the difference of age,smoking rate,anti cyclic citrullinated peptide antibody levels,the number of swollen joints,tenderness joints of patients in the RA-ILD group were being statistically signiifcant(P< 0.05).There was no signiifcant difference between the course of disease,erythrocyte sedimentation rate,C-reactive protein,rheumatoid factor,DAS28 score in the two groups(P> 0.05).Conclusion:The age,smoking rate and anti cyclic citrullinated peptide antibody levels of patients in the RA-ILD group can predict the occurrence of interstitial lung disease and related risk factors of patients should be checked out with high-resolution CT as early as possible.%目的：分析类风湿关节炎（RA）合并肺间质病变（ILD）患者的临床及实验室指标，探讨其发病特点及危险因素，以利于及早诊治。方法：将256例住院RA患者根据肺部高分辨率CT结果分为单纯RA组187例和RA-ILD组69例，比较2组患者一般资料、实验室资料及病情评价。结果：RA-ILD组患者年龄、吸烟率、抗环瓜氨酸肽抗体、肿胀关节数、压痛关节数与单纯RA组比较，差异有统计学意义（P <0.05）。2组病程、红细胞沉降率、C-反应蛋白、类风湿因子、DAS28评分比较，差异无统计学意义（P >0.05）。结论：RA患者的年龄、吸烟情况、抗环瓜氨酸肽抗体水平可预测肺间质病变的发生，有相关危险因素的患者应尽早行高分辨率CT检查。