类风湿关节炎合并肺间质病变的发病相关因素

摘要

目的 分析类风湿关节炎(RA)合并肺间质病变(ILD)的临床及实验室特点,探讨其发病相关因素.方法 分析76例RA患者的临床资料,分为单纯RA组(n=40)和RA-ILD组(n=36),比较两组患者的一般情况、临床表现以及实验室指标.结果 两组在年龄、关节肿痛数目、血管炎及发热阳性率、CRP、RF、IgM、白细胞计数比较差异具有统计学意义(P<0.05).结论 年龄大,RF高滴度表达,RA病情重,伴有关节外表现的RA患者易合并ILD,应尽早行高分辨CT等检查早期诊断及治疗.%Objective To analyze the clinical characteristics and laboratory data of rheumatoid arthritis ( RA ) patients complicated with interstitial lung disease ( ILD ) and to investigate the associated risk factors causing HA-ILD. Methods 76 RA patients were divided into the RA group ( n = 40 ) and the RA-ILD group ( n = 36 ), and their clinical data were analyzed retrospectively. The general state of health, clinical manifestations, and levels of serum markers were compared between the two groups. Results The ages, the counts of involved joints, the positive rate of vasculitis and fever, the serum levels of CRP, RF, IgM and the number of white blood cells were obviously higher in the RA-ILD group than in the RA group with statistical significance ( P < 0. 05 ). Conclusions Chest HRCT should be taken to get early diagnosis and treatment of ILD in patients with RA, especially in the elder patients with high titer of RF, severer disease of RA and extra articular manifestations.