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风湿病与关节炎

风湿病与关节炎

Rheumatism and Arthritis
本刊是面向国内外发行的突出中国风湿病学特色的专业学术期刊，以风湿病的临床诊断、治疗、护理、康复、预防为主，涵盖与之相关的中医、西医、中西医结合等专业，突出临床实用性。办刊宗旨：报道风湿病与关节炎领域最新研究成果和临床实践经验，搭建学术交流平台，为提高我国风湿病与关节炎疾病诊疗水平服务。本刊内容中西并重，突出实用。读者对象：中医、西医、中西医结合风湿病与关节炎医疗、教学、科研工作者及中医大中专院校的风湿骨伤专业学生。
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  • 发文量：2236
  • 被引量：6789
  • H指数：0
  • 开始收录时间：2012,1(1)
  • CNKI综合因子：1.011
  • 维普期刊影响因子： 1.59
  • 万方期刊影响因子：1.22
  • 创刊时间：2012
  • 国内刊号/CN：10-1073/R
    国际刊号/ISSN：2095-4174
  • 发行周期：月刊
    邮发代号：36-363
  • 主管单位：中国科学技术协会
    主办单位：中华中医药学会
风湿病与关节炎-联系信息
  • 主编：娄多峰
  • 电话：010-64822337
  • 邮箱：fsbygjy@163.com
  • 地址：北京市朝阳区北四环东路115号院6号楼109室
  • 邮编：100101
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风湿病与关节炎 >2023年第10期

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  • 摘要：类风湿关节炎治疗方法主要包括药物治疗、功能锻炼、物理治疗、手术治疗。国内外学者均强调非药物治疗的重要性，综述类风湿关节炎患者物理疗法现状及运用进展，以期为今后临床开展类风湿关节炎物理疗法提供思路和依据。
  • 摘要：目的：观察加味益气丸联合养血止痛丸治疗骶髂关节致密性骨炎的临床疗效及安全性。方法：将54例骶髂关节致密性骨炎患者随机分为治疗组和对照组，每组27例。治疗组口服加味益气丸和养血止痛丸，每次各6 g，每日2次；对照组口服塞来昔布胶囊，每次200 mg，每日2次。两组均以4周为1个疗程。观察两组治疗前和治疗3，7，14，28 d 及治疗结束2周后 NRS 评分改善情况及临床疗效，并对不良反应进行评价。结果：治疗组治愈7例，显效13例，好转5例，无效2例，总有效率为92.59%；对照组治愈2例，显效5例，好转11例，无效8例，总有效率为69.23%。两组比较，差异有统计学意义（P <0.05）。治疗后，两组各时间点 NRS 评分较治疗前均有下降，差异有统计学意义（P <0.05）。组间比较，治疗3，7 d 及治疗结束2周后，NRS 评分治疗组高或低于对照组，差异有统计学意义（P <0.05）；治疗14，28 d 时，差异无统计学意义（P >0.05）。结论：加味益气丸联合养血止痛丸治疗致密性髂骨炎安全有效，值得推广应用。%[ABSTRACT] Objective:To observe the clinical effect and safety of Jiawei Yiqi Wan(加味℃气丸) combined with Yangxue Zhitong Wan(养血止痛丸) in the treatment of sacroiliac joint sclerosing osteitis.Methods:54 cases of sacroiliac joint sclerosing osteitis were randomly divided into a treatment group and a control group, 27 cases in each.The treatment group was orally given Jiawei Yiqi Wan and Yangxue Zhitong Wan,6 g each time and twice a day;while the control group was orally given celecoxib capsule,200 mg each time and twice a day. The two groups were treated for 4 weeks,observing NRS scores and clinical efficacy before treatment,after 3,7,14 , 28 days,and 2 weeks after treatment,and evaluating their adverse reactions.Results:In the treatment group, 7 cases were cured,13 cases were markedly effective,5 cases were improved,and 2 cases were ineffective,the total effective rate being 92.59%,while in the control group,2 cases were cured,5 cases were markedly effective, 11 cases were improved,and 8 cases were ineffective,the total effective rate being 69.23%.The difference between the two groups was statistically significant (P < 0.05).After treatment,the NRS pain scores of the two groups were significantly lower than those before treatment,and the difference was statistically significant (P < 0.05). After 3 days,7days and 2 weeks of treatment,the NRS scores of the treatment group were significantly lower than those of the control group,and the difference was statistically significant (P < 0.05).After 14 and 28 days of the treatment,the difference between groups was not statistically significant (P > 0.05). Conclusion:Jiawei Yiqi Wan combined with Yangxue Zhitong Wan is safe and effective in the treatment of sclerosing osteitis,worthy of popularization and application.
  • 摘要：目的：观察活络骨康丸联合髓芯减压及自体骨移植术治疗早期股骨头坏死的临床疗效。方法：采用髓芯减压及自体骨移植术治疗早期股骨头坏死患者24例28髋，术后所有患者均口服活络骨康丸，服药时间为24个月，随访观察治疗前后髋关节功能 Harris 评分及临床疗效。结果：所有患者均获得随访，末次随访见患者髋关节功能较治疗前均有明显改善，未发生关节塌陷及二次手术者；术前及术后2年 Harris 评分比较，差异有统计学意义（P <0.05）。结论：活络骨康丸联合髓芯减压及自体骨移植术治疗早期股骨头坏死可明显缓解疼痛症状、改善关节功能，效果满意。
  • 摘要：肾虚血瘀是类风湿关节炎的重要病机之一，目前以补肾活血法治疗在临床上取得了较好的疗效。通过对类风湿关节炎的发病机制以及对近年来运用补肾活血法治疗类风湿关节炎的临床研究、基础研究现状进行分析，探讨补肾活血法治疗类风湿关节炎的研究现状和优势，以期更好地指导临床治疗。
  • 摘要：评析新安医家论治痹病特色医案：汪机，治痹喜用参芪，固本培元；孙一奎，治痹强调温补，益肾健脾；程文圃，治痹注重气血，治病求本；郑重光，治痹擅使姜附，扶阳通脉。
  • 摘要：痛风缓解期的辨治对稳定尿酸水平、减少复发、提高患者依从性等尤为重要。文章从脾胃、肝肾、痰湿、瘀血、气血等方面综述痛风缓解期的辨治思路。
  • 摘要：目的：从Wnt/β-catenin信号通路观察透骨消痛胶囊对大鼠膝骨关节炎关节软骨的保护作用。方法：60只健康清洁级2月龄雄性SD大鼠，随机分为正常对照组、模型对照组和透骨消痛胶囊组，每组20只。模型对照组和透骨消痛胶囊组采用质4%木瓜蛋白酶双膝关节腔注射，成功复制骨关节炎模型后，透骨消痛胶囊组给予透骨消痛胶囊287.5 mg·kg-1，正常对照组和模型对照组给予相同剂量的生理盐水。给药2个月后，采用Western blot法观察各组关节软骨中含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶-5（ADAMTS-5）、Wnt-4、β-catenin和基质金属蛋白酶-13（MMP-13）的表达。结果：与正常对照组比较，模型对照组ADAMTS-5、Wnt 4、β-catenin和MMP-13表达升高（P <0.05）；与模型对照组比较，透骨消痛胶囊组ADAMTS-5、Wnt4、β-catenin和MMP-13表达降低（P <0.05）。结论：透骨消痛胶囊对关节软骨的保护作用与其降低Wnt/β-catenin信号通路表达相关。
  • 摘要：类风湿关节炎动物模型一直是研究的重点，提供与人类风湿关节炎类似的动物模型，有助于深入研究本病的发病机制和治疗策略。然而，不同的动物模型特点也不尽相同，应根据实验需求选择合适的模型。通过整理目前国内外类风湿关节炎模型研究，综述几种常用的实验性类风湿关节炎模型的建立方法、发病机制和特点，以期为类风湿关节炎的深入研究及防治提供依据。
  • 摘要：目的：观察平乐正骨传统膏药活血接骨止痛膏联合萘丁美酮治疗腰椎间盘突出症的临床疗效。方法：将100例腰椎间盘突出症患者随机分为治疗组和对照组，每组50例。对照组给予核心肌力训练及萘丁美酮胶囊口服治疗，治疗组在对照组治疗的基础上联合活血接骨止痛膏外敷。7d为1个疗程，共3个疗程。治疗前后采用JOA下腰痛评分（JOA评分）、Oswestry腰背部功能障碍指数（ODI指数）进行评定，并比较两组临床疗效。结果：治疗组完成治疗41例，优5例，良23例，可8例，差5例，优良率为68.29%；对照组完成治疗42例，优2例，良15例，可11例，差14例，优良率为40.48%。两组比较，差异有统计学意义（P<0.05）。治疗后，两组JOA评分、ODI指数较治疗前均有明显改善（P<0.05）；且治疗组优于对照组（P<0.05）。结论：腰背肌肌力训练联合口服萘丁美酮胶囊对腰椎间盘突出症有一定疗效，辅以活血接骨止痛膏效果更加显著，活血接骨止痛膏外敷是腰椎间盘突出症保守治疗的有效辅助疗法。%Objective:To observe the clinical efficacy of Huoxue Jiegu Zhitong Gao( 活血接骨止痛膏) combined with nabumetone in the treatment of lumbar disc herniation.Methods:One hundred cases of lumbar disc herniation were randomly divided into a treatment group and a control group,50 cases in each.The control group was given the core strength training and nabumetone capsule,while the treatment group was given external application of Huoxue Jiegu Zhitong Gao based on the treatment of the control group,7 days for 1 course and 3 courses altogether.Before and after the treatment,both groups were evaluated with JOA low back pain curative effect evaluation (JOA score) and Oswestry lumbar dysfunction index(ODI) and their clinical curative effects were compared.Results:In the treatment group,41 cases finished their treatment,among which 5 cases were excellent,23 cases were better,8 cases were good,and 5 cases were not good,the fineness rate being 68.29%;while in the control group,42 cases finished their treatment among which 2 cases were excellent,15 cases were better, 11 cases were good,and 14 cases were not good,the fineness rate being 40.48%.The difference between the two groups was statistically significant (P < 0.05).After treatment,the JOA score and ODI of the two groups were significantly improved compared with those before treatment (P < 0.05),and the treatment group was better than the control group (P < 0.05).Conclusion:Low back muscle strength training combined with nabumetone capsule has a certain curative effect on lumbar disc herniation,more obvious combined with Huoxue Jiegu Zhitong Gao. External application of Huoxue Jiegu Zhitong Gao is an adjuvant therapy in the conservative treatment of lumbar disc herniation.
  • 摘要：目的：观察冲击波联合上肢洗伤方熏洗治疗肱骨外上髁炎的疗效。方法：选取79例肱骨外上髁炎患者，均予痛处冲击波治疗，5 d治疗1次，4次为1个疗程；并于冲击波治疗后第1天开始，加用上肢洗伤方熏洗局部，隔日熏洗1次，连续熏洗8次为1个疗程，配合冲击波治疗2～3个疗程。结果：失访及因故退出5例，其余74例中，痊愈37例，显效18例，有效14例，无效5例，总有效率为93.24%。未次随访时疼痛VAS评分明显低于治疗前，差异有统计学意义（P<0.01）；治疗后，握力指数较治疗前大幅度增加，差异有统计学意义（P<0.01）。结论：冲击波联合上肢洗伤方熏洗治疗肱骨外上髁炎临床疗效显著，二者联合有协同作用，安全有效，值得在临床推广应用。
  • 摘要：成人斯蒂尔病中西医结合治疗不仅可调节免疫，同时可减轻糖皮质激素及慢作用抗风湿药物的不良反应，降低疾病的复发率，日益显示出其优越性。刘健教授运用中医辨证思维治疗成人斯蒂尔病，取得了较好的疗效，为临床诊疗提出了新方法。
  • 摘要：[ABSTRACT]Objective:To observe the effect of invigorating kidney and anti rheumatism prescription Hanbi Kang Tang(寒痹康汤) on the RANKL/RANK/OPG bone tissue system of CIA rats to reveal its mechanism of anti- Rheumatoid Arthritis bone erosion.Methods:Bovine type II collagen emulsified with Freund’s incomplete adjuvant was used to induce CIA rat models.Sixty Wistar rats were randomly divided into a normal control group,a model control group,a methotrexate group,and Hanbi Kang high,medium and low dose groups.The methotrexate group was used as an object of reference to observe the influence of difference doses of Hanbi Kang Tang on the expression of rat bone tissue RANKL,RANK and OPG.Results:Compared with the normal control group,the expressions of RANKL mRNA,RANK mRNA,RANKL,and RANK proteins in rats of the model control group increased,while the expressions of OPG mRNA and OPG proteins decreased(P< 0.01). Compared with the model group,the expressions of RANKL mRNA,RANK mRNA,RANKL,and RANK proteins in rats of the Hanbi Kang groups and the methotrexate group decreased in different degree,while the expression of OPG mRNA and OPG proteins decreased (P< 0.01 or P< 0.05),among which the 　　Hanbi Kang high dose group was the most obvious,with no signiifcant difference compared with the methotrexate group(P> 0.05).Hanbi Kang could inhibit the progression of arthritis in CIA rats,improving the expressions of OPG protein and gene in bone tissue,and inhibiting the expressions of RANKL and RANK proteins and gene. Conclusion:Hanbi Kang Tang has the effect of anti-RA bone erosion,whose mechanism may be related to the regulation of OPG/RANKL/RANK osteoclast differentiation regulating signal transduction system.%目的：观察补肾抗风湿方药寒痹康汤对CIA大鼠骨组织RANKL/RANK/OPG系统的影响，揭示其抗类风湿关节炎骨质侵蚀的作用机制。方法：采用弗氏不完全佐剂乳化的牛Ⅱ型胶原蛋白诱导CIA大鼠模型，将60只Wistar大鼠随机分为正常对照组，模型对照组，甲氨蝶呤组，寒痹康汤高、中、低剂量组，以甲氨蝶呤组为对照，观察不同剂量寒痹康汤对CIA大鼠骨组织RANKL、RANK和OPG表达水平的影响。结果：与正常对照组比较，模型对照组大鼠骨组织的RANKL mRNA、RANK mRNA、RANKL蛋白、RANK蛋白的表达升高，OPG mRNA、OPG蛋白的表达下降（P<0.01）；与模型对照组比较，寒痹康汤各剂量组和甲氨蝶呤组的RANKL mRNA、RANK mRNA、RANKL蛋白、RANK蛋白的表达均有不同程度的下降，OPG mRNA、OPG蛋白的表达均有不同程度的升高（P<0.01或P<0.05），其中以寒痹康汤高剂量组最明显；寒痹康汤高剂量组与甲氨蝶呤组比较，差异无统计学意义（P>0.05）。结论：寒痹康汤能抑制CIA大鼠的关节炎严重度，提高骨组织中OPG蛋白和基因表达，抑制RANKL和RANK的蛋白和基因表达，提示其具有抗类风湿关节炎骨质侵蚀的作用，机制可能与调控OPG/RANKL/RANK破骨细胞分化调节信号传导系统有关。
  • 摘要：肩痹为肢体痹之一，是按肢体部位分类的风湿病三级痹病。历史上对于肩痹相关论述有着丰富的文献记载。通过对肩痹有关历代文献的整理和研究，包括肩痹的病名、肩痹的病因病机、历代医家对肩痹的论述，及肩痹的治疗等，以便能更清晰地认识肩痹，更好地应用于临床。
  • 摘要：总结近几年针刀治疗膝骨关节炎机制研究、治疗点的选取、操作方法、临床应用和临床研究中应该面对的问题等，对针刀治疗膝骨关节炎的文献进行综述，为进一步研究奠定基础。
  • 摘要：目的：观察甲氨蝶呤联合狼疮I号方治疗系统性红斑狼疮的疗效。方法：选择经西药规范治疗1年以上，病情仍未控制的系统性红斑狼疮患者30例，停用就诊时所用西药环磷酰胺、硫唑嘌呤、吗替麦考酚酯胶囊，改用甲氨喋呤每周1次，每次10 mg，加用狼疮I号方每日1剂，水煎服。治疗时间为1年。结果：临床缓解13例，显效16例，有效1例，总有效率为100%。实验室指标较治疗前均有显著改善（P <0.05）。结论：单用西药治疗系统性红斑狼疮控制不理想时，以甲氨蝶呤联合狼疮I号方治疗有效。
  • 摘要：王海云教授认为，骨关节炎属本虚标实证，以年老体弱、肝肾亏虚为本，风、寒、湿、热、瘀阻经络为标，治疗分别给予散寒除湿、清热利湿、补益肝肾、活血化瘀之法，分型论治。
  • 摘要：Objective:To observe the clinical effect of external and internal application of Chinese medicine combined with sodium hyaluronate in the treatment of medium-severe knee osteoarthritis.Methods: 60 cases of medium-severe knee osteoarthritis were randomly divided into a control group and a treatment group, 30 cases in each.The treatment group was orally given modified Duhuo Jisheng Tang(独活寄生汤),externally applied Shuanghuang San(双黄散)and given intra-articular injections of sodium hyaluronate.While the the control group was orally given diacerein capsules,externally applied piroxicam patches and given intra-articular injections of sodium hyaluronate.The treatment course was 3 weeks.The clinical effects,VAS scores and WOMAC scores of the two groups before and after treatment were observed.Results:In the treatment group,3 cases were cured,8 cases were markedly effective,4 cases were effective,and 15 cases were ineffective,the total effective rate being 86.67%;while in the control group,3 cases were cured,7 cases were markedly effective,6 cases were effective,and 14 cases were ineffective,the total effective rate being 80%.There was no significant difference between the two groups(P > 0.05).After treatment,the VAS scores and WOMAC scores of the two groups were significantly improved(P < 0.05),and the treatment group was better than the control group(P < 0.05). Conclusion:External and internal application of Chinese medicine combined with sodium hyaluronate has a certain curative effect in the treatment of medium-severe knee osteoarthritis on the aspects of improving clinical symptoms,relieving joint pain,and improving joint function,worthy of clinical promotion.%目的：观察中药内服外用联合玻璃酸钠治疗中重度膝骨关节炎的临床疗效。方法：将60例中重度膝骨关节炎患者随机分为对照组和治疗组，每组30例。治疗组辨证给予口服独活寄生汤加减，外敷双黄散，关节腔内注射玻璃酸钠；对照组给予口服双醋瑞因胶囊，外用吡罗昔康贴片，关节腔内注射玻璃酸钠。3周为1个疗程。观察两组患者临床疗效，治疗前后膝关节视觉模拟评分法（VAS）评分及西安大略和麦克马斯特大学骨关节炎调查表（WOMAC）评分。结果：治疗组临床治愈3例，显效8例，有效15例，无效4例，总有效率为86.67％；对照组临床治愈3例，显效7例，有效14例，无效6例，总有效率为80.00％。两组比较，差异无统计学意义（P>0.05）。治疗后，两组膝关节VAS评分、WOMAC评分较治疗前均有显著改善（P<0.05），且治疗组优于对照组（P<0.05）。结论：中药内服外用联合玻璃酸钠治疗中重度膝骨关节炎，在改善患者临床症状、减轻关节疼痛、改善关节功能方面疗效确切，值得临床推广。
  • 摘要：老年风湿病的预防和护理尤其重要，根据老年风湿病的特点，提出从4个方面进行防护：药物治疗，重视脾胃，兼顾肝肾；精神抚慰，坚定信念，多些关爱；功能锻炼，循序渐进，贵在坚持；生活调摄，起居有常，饮食有节。
  • 摘要：从儿童暂时性髋关节滑膜炎的病因病机、临床表现、诊断及治疗方法等方面，对其研究现状进行综述，以加深对本病的认识。
  • 摘要：目的：观察中西医综合治疗成人髋关节滑膜炎的疗效。方法：回顾性分析43例成人髋关节滑膜炎患者，均采用羌透方熏洗、骨炎膏外敷，七叶皂苷钠、喜炎平静脉输注及患肢牵引等治疗，治疗时间7～20 d。结果：43例54髋中治愈43髋，好转9髋，未愈2髋，总有效率为96.30%。随访9～20个月，1例失去随访，3例因劳累复发再次治疗后痊愈出院。结论：中西医综合治疗成人髋关节滑膜炎疗效显著，值得临床应用与推广。
  • 摘要：痛风是由于嘌呤代谢紊乱致血尿酸升高,尿酸盐沉积在关节滑膜等其他组织而引起的一临床综合征。随着人们生活水平的提高、饮食结构的改变,痛风的发病率也呈逐年升高的趋势。由于痛风石可以在人体大多数软组织沉积,故其临床表现亦有不同,甚或有时难与其他类型风湿病鉴别。笔者在临床上观察到以腰骶部、膝关节等外周关节疼痛为主要临床表现的痛风患者1例,报告如下。1病例资料患者,男,27岁,以反复关节疼痛2年,
  • 摘要：对干燥综合征的病因病机、辨证论治、辨病治疗等方面的研究进展进行较为详细的阐述。
  • 摘要：通过对近年中医学领域有关类风湿关节炎临床及基础研究文献进行统计总结，综述中医药治疗类风湿关节炎的研究成果。从病因病机角度出发探讨辨证治疗，为中医药治疗本病提供更多的参考；了解目前中医药针对类风湿关节炎的治疗及研究现状。
  • 摘要：目的：观察圣愈汤合五苓散加减治疗膝骨关节炎合并滑膜炎的临床疗效。方法：将120例膝骨关节炎合并滑膜炎患者随机分为治疗组和对照组，每组60例。对照组给予双氯芬酸钠肠溶片口服治疗，治疗组以圣愈汤合五苓散加减辨证治疗。两组均以30 d为1个疗程。观察两组临床疗效及膝关节功能评分。结果：治疗组治愈16例，显效21例，有效18例，无效5例，总有效率为91.67%；对照组治愈7例，显效16例，有效23例，无效14例，总有效率为76.67%。两组比较，差异有统计学意义（P<0.05）。治疗后，两组膝关节功能评分较治疗前均有改善（P<0.05），且治疗组优于对照组（P<0.05）。随访1年，治疗组的复发率为13.33%，明显低于对照组的45.00%，差异有统计学意义（P<0.05）。结论：圣愈汤合五苓散加减治疗膝骨关节炎合并滑膜炎疗效显著，值得临床推广。%Objective:To observe the clinical curative effect of modified Shengyu Tang(圣愈汤) combined with Wuling San( 五苓散)in the treatment of knee osteoarthritis complicating synovitis.Methods: One hundred and twenty cases of patients with knee osteoarthritis complicating synovitis were randomly divided into a treatment group and a control group,60 cases in each.The control group was orally given Diclofenac Sodium Enteric Coated Tablets;while the treatment group was treated with modified Shengyu Tang combined with Wuling San according to syndrome differentiation.Both groups were treated for 30 days.The clinical efficacy and knee function scores of the two groups were observed.Results:In the treatment group,16 cases were cured,21 cases were markedly effective,18 cases were effective,and 5 cases were ineffective,the total effective rate being 91.67%;while in the control group,7 cases were cured,16 cases were markedly effective,23 cases were effective,and 14 cases were ineffective,the total effective rate being 76.67%.The difference between the two groups was statistically significant (P < 0.05).After treatment,the knee joint function scores of the two groups were more improved than those before treatment (P < 0.05),and the treatment group was better than the control group (P < 0.05). According to one year follow-up,the recurrence rate of the treatment group was 13.33%,which was significantly lower than that of the control group (45.00%),and the difference between them was statistically significant (P< 0.05).Conclusion:The curative effect of Shengyu Tang combined with Wuling San in the treatment of knee osteoarthritis complicating synovitis is obvious,worthy of promotion.
  • 摘要：娄多峰教授将风湿病病因病机概括为虚、邪、瘀3个方面，总结出一套治疗风湿病的完整体系。通过梳理娄多峰教授的临床经验、学术思想、医风医德等，总结其学术思想及治疗风湿病经验，以更好地推动名老中医学术思想的传承和中医药事业的发展。
  • 摘要：总结近十年来独活寄生汤在腰椎间盘突出症、强直性脊柱炎、膝骨关节炎、骨质疏松、肩关节周围炎，以及其他骨伤科疾病的临床应用，并进一步综述独活寄生汤在以上相应疾病中的实验研究进展，为其在骨伤科疾病的治疗提供依据与指导。
  • 摘要：Objective:To observe the clinical effect of treating knee osteoarthritis by oral administration of and external washing with traditional Chinese medicine (TCM).Methods:180 cases of knee osteoarthritis were randomly divided into a treatment group and a control group,90 cases in each.Patients in the control group were given Glucosamine Sulfate Capsules,0.3 g each time,3 times a day;and Diclofenac Sodium Sustained Release Capsules,0.1 g each time,once a day.Based on the treatment of the control group,the treatment group was treated by oral administration of and external washing with TCM.The two groups were treated with 30 days as 1 course,observing their clinical efficacy,knee joint functional classification and pain grading.Results:In the treatment group,13 cases were cured,65 cases were markedly effective,8 cases were effective,and 4 cases were invalid,the total effective rate being 95.56%;while in the control group,4 cases were cured,25 cases were markedly effective,31 cases were effective,and 30 cases were ineffective,the total effective rate being 66.67%.The difference between the two groups was statistically significant (P < 0.05).After treatment,the knee joint functional classification and pain grading of the two groups were improved compared with those before the treatment (P < 0.05),and the treatment group was better than the control group (P < 0.05).Conclusion:Oral administration of and external washing with TCM in the treatment of knee osteoarthritis has an obvious curative effect,it is worthy of further popularization and application.%目的：观察中药内服外洗治疗膝骨关节炎的临床疗效。方法：将180例膝骨关节炎患者随机分为治疗组和对照组，每组90例。对照组服用硫酸氨基葡萄糖胶囊每次0.3 g，每日3次；双氯芬酸钠缓释胶囊每次0.1 g，每日1次。治疗组在对照组治疗的基础上加用中药内服及局部外洗。两组均以30 d为1个疗程。观察两组临床疗效及膝关节功能分级、疼痛分级。结果：治疗组治愈13例，显效65例，有效8例，无效4例，总有效率为95.56%；对照组治愈4例，显效25例，有效31例，无效30例，总有效率为66.67%。两组比较，差异有统计学意义（P<0.05）。治疗后，两组膝关节功能分极、疼痛分级较治疗前均有改善（P<0.05），且治疗组均优于对照组（P<0.05）。结论：中药内服外洗联合运用治疗膝骨关节炎有明显疗效，值得进一步推广应用。
  • 摘要：王承德教授首先提出痹必夹湿的观点，认为痹始于湿，病机于湿，变生于湿，治难在湿，理清寒、湿、热辨证要点，强调治疗风湿病应重视扶正培本，首重脾胃，以健脾化湿为治疗大法，对各型风湿病的疗效均显著。
  • 摘要：Objective:To investigate the effectiveness and safety of Buzhong Yiqi Decoction combined with low molecular weight heparin calcium in preventing the formation of deep venous thrombosis in lower extremity after hip operation.Methods:148 cases were randomly divided into the treatment group (75 cases) and the control group (73 cases),the former given Buzhong Yiqi Decoction combined with low molecular weight heparin calcium and the latter treated by low molecular weight heparin calcium after operation.Comparison of the deep venous thrombosis of lower extremity and the incidence of adverse reactions of the two groups was made and the blood platelet count (BPC) and four items of blood coagulation were detected after 3 days of operation.Results:There were 6 patients with deep venous thrombosis of lower extremity after operation in the treatment group,the incidence rate being 8.00%,and there were 10 patients with deep venous thrombosis of lower extremity after operation in the control group,the incidence rate being 13.70%.The difference between the two groups was statistically significant (P < 0.05).The differences of BPC,hemoglobin,prothrombin time,activated partial thromboplastin time and the incidence of adverse reactions between the two groups were not statistically significant (P > 0.05).Conclusion:Buzhong Yiqi Decoction combined with low molecular weight heparin calcium in the prevention of deep vein thrombosis after hip operation had an curative effect,with no inlfuence on blood coagulation mechanism,safe and worthy of clinical application.%目的：探讨补中益气汤配合低分子肝素钙对预防髋关节术后下肢深静脉血栓的疗效。方法：将148例患者随机分为治疗组75例和对照组73例。治疗组于术后给予补中益气汤配合低分子肝素钙，对照组仅给予低分子肝素钙。比较两组术后下肢深静脉血栓及不良反应的发生率，并于术后第3天检测患者血小板计数及凝血四项。结果：治疗组术后下肢深静脉血栓6例，发生率为8.00%，对照组术后下肢深静脉血栓10例，发生率为13.70%，两组比较，差异有统计学意义（P<0.05）。两组患者血小板计数、血红蛋白、凝血酶原时间、活化部分凝血活酶时间及不良反应发生率相比较，差异均无统计学意义（P>0.05）。结论：补中益气汤配合低分子肝素钙预防髋关节术后深静脉血栓形成疗效确切，对凝血机制无影响，安全性好。

    风湿病与关节炎的期刊信息

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