微孢子虫基因组学及分子流行病学研究进展

摘要

With the completion of the genomes of many Microsporidia species,the comparative genomics and functional genomics have become the major research tasks of Microsporidia and that will provide significant data for illuminating the pathogenesis of Microsporidia.Meanwhile,investigating on the prevalence of Mi-crosporidia using the molecular epidemiology method revealed that Microsporidia wide spread in silkworm, mammal and aquaculture animals,which could provide a reference for studying the epidemic characteristics. Based on the more than 100 years of Microsporidia researches,the future work will refine the genomics and molecular epidemiology study and achieve new breakthroughs in the pathogenic mechanism and molecular diagnostics of Microsporidia.%随着多种微孢子虫全基因组的测序完成,微孢子虫的基因组学研究,尤其是比较基因组学和功能基因组学方面成为微孢子虫的研究热点,这能够为进一步阐明其致病机制提供依据.同时,近年来对微孢子虫的分子流行病学研究发现,微孢子虫在我国蚕、水产动物及哺乳动物中大量流行,也在我国人群中流行,对其在各个宿主的分子流行病学进行概述,能够为研究其流行规律及趋势提供参考.人类研究微孢子虫已有100多年的历史,在此基础上,预计未来对微孢子虫的基因组学研究和分子流行病学研究还将进一步完善,并在其侵染机制、分子诊断等方面取得新的突破.