首页> 美国政府科技报告 >Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core
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Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core

机译:跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体(aR)在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

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This Prostate Cancer Center initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups (African-Americans, Latinos, Whites, Japanese) at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the Hawaii/Los Angeles Multiethnic Cohort study. Two hundred thirty-nine tissue samples have been received and processed histopathologically by Project C, which has begun immunohistochemical staining for COX-2, p27, p2l, p16 and Caveolin-l markers with additional markers to follow. Project B, studying the androgen receptor (AR) gene in detail, has identified 54 sequence variants in 90 samples analyzed to date. Two functional assays were developed this year to better assess these sequence variants. In Project A, studying the SRD5A2 gene in detail, in 87 tumors, the 13 mutations detected to date have been reconstructed by site-directed mutagenesis.

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