肿瘤相关巨噬细胞与肿瘤关系的研究进展

摘要

Tumor associate macrophages ( TAMs) play a significant role in the interaction of tumor inflam-mative microenvironment and tumor cells .TAMs originate from monocytic precursors ,recruiting into tumor tissue by colony stimulating factor ( CSF) .This review summarized that TAMs promote tumor progression and metastasis though angiogenesis ,lymphogenesis , immunosuppression , matrix remodeling and affecting cancer stem cells .The article pointed that targeting TAMs is a new strategy for future tumor therapy .%肿瘤相关巨噬细胞（ Tumor associate macrophages ，TAMs）是肿瘤的炎症微环境与肿瘤细胞间的重要信使。它是从血液中的单核细胞演变而来，主要通过集落刺激因子（ Colony -stimulating factor ， CSF）趋化至肿瘤组织中。本文简述了TAMs通过影响血管生成和淋巴管生成，抑制免疫，调节基质，与干细胞相互作用等方面促进肿瘤的进展。分析表明靶向于TAMs的治疗策略是未来治疗肿瘤的一个新方向。