女性宫颈病变患者HPV感染分布特点meta分析

摘要

目的 分析女性宫颈病变患者HPV感染分布特点,了解高危HPV型别,以便有针对性进行预防和诊治.方法 通过知网、万方、维普等查询期刊和论文,并参考相关宫颈病变mate分析文献,对全国范围内宫颈病变患者HPV感染分布进行统计分析,对不同型别的HPV在不同组织类别中的感染率进行比较,筛选高危型别进行进一步的差异分析.结果 慢性宫颈炎患者HPV感染率为26.99％,宫颈上皮内瘤样变患者HPV感染率为86.94％,宫颈癌患者HPV感染率为94.09％,三者差异有统计学意义(P ＜0.05).12种高危HPV型别中,综合感染率前五的HPV型别依次是HPV16＞ HPV18＞ HPV58＞ HPV52＞ HPV31,感染率分别为58.75％、6.04％、4.33％、2.97％、2.28％;对比分析前三位高危型HPV16、18、58在慢性宫颈炎组和宫颈病变组的感染率差异,HPV16、HPV18在慢性宫颈炎组和宫颈病变组感染率差异有统计学意义(P ＜0.05),HPV58在慢性宫颈炎组和宫颈病变组感染率差异无统计学意义(P＞ 0.05).结论 不同型别的HPV在不同组织类别中的分布有差异,这种差异可以用来有针对性地研制疫苗,达到对宫颈癌更好的预防和治疗.%Objective To analyze the distribution of HPV infection in women with cervical lesions. Know the type of high-risk HPV, in order to facilitate targeted prevention and treatment. Methods By means of journals, essays and other related journals and papers, and referring to the relevant mate analysis of cervical lesions, the statistical analysis of the distribution of HPV infection in patients with cervical lesions across the country was carried out. In different types of HPV, Infection rate comparison, screening for high-risk type for further analysis of differences. Results HPV infection rate was 26. 99％ in patients with chronic cervicitis, HPV infection rate in cervical intraepithelial neoplasia was 86. 94％, HPV infection rate in cervical cancer was94. 09％, the difference was statistically significant (P ＜ 0. 05). Among the 12 high-risk HPV types, the HPV types with the highest comprehensive infection rates were HPV16＞ HPV18＞ HPV58＞ HPV52＞ HPV31 in succession, and the infection rates were 58. 75％, 6. 04％, 4. 33％, 2. 97％ and 2. 28％ The infection rates of HPV16, HPV18 and HPV18 in patients with chronic cervicitis and cervical lesions were significantly different (P ＜ 0. 05). The infection rate of HPV58 in patients with chronic cervicitis and cervical lesions was significantly different Cervicitis group and cervical lesions group infection rate difference was not statistically significant (P＞ 0. 05). Conclusion There are differences in the distribution of different types of HPV in different tissue types. This difference can be used to develop targeted vaccines to achieve better prevention and treatment of cervical cancer.