To explore efficacy and safety of gemcitabine combined with Oxaliplatin and Prednisone ( GPP) in the treatment of patients with elderly relapsed and refractory NHL . Methods 34 cases pathologically and immunohistochemi-cally confirmed, stage Ⅲ ~ Ⅳ elderly relapsed and refractory NHL were treated with GEM 800~1 000 mg/m2 in 60 minutes on dl ,8;L-OHP 75 mg/m2 in dl ;and PDN 40 mg/m2 ,p. o, on d1 ~ 5. The chemotherapy was repeated every 21 ~28 days. Treatment results were evaluated after two cycles of chemotherapy . Results Of 34 assessable patients , the complete response ( CR ) and the partial response (PR) were seen in 9 and 16 cases,respectively. 4 patients had stable disease and 5 patients had progressed disease. The overall response rate (CR + PR) was 73. 5% . Grade Ⅲ ~ Ⅳ bone marrow suppression was seen in 10 cases,with an incidence rate of 29. 4% . There was no treatment related death. Conclusion Gemcitabine plus oxaliplatin and pred -nisolone are effective in the treatment of elderly patients with relapsed or refractory NHL .%目的 探讨吉西他滨联合奥沙利铂、强的松治疗老年复发难治性淋巴瘤的疗效及安全性.方法 34例经病理及免疫组化诊断证实的Ⅲ～Ⅳ期老年复发难治NHL.GEM 800~1 000 mg /m2+生理盐水100 ml静脉滴注 60 min,第1,8天;L-OHP 75 mg /m2+5% 葡萄糖注射液250 ml静脉滴注 3～4 h,第1天;强的松20~40 mg/m2,口服,第1~5天.21~28天为1个周期,完成 2 个周期以上者做疗效评价.结果 34例患者中完全缓解(CR)9例,部分缓解(PR)16例,稳定(SD )4例,进展(PD )5例,总有效率73.5%.骨髓抑制Ⅲ～Ⅳ度10例,发生率29.4%,未发生治疗相关性死亡.结论 吉西他滨联合奥沙利铂、强的松治疗老年复发难治性NHL效果肯定,属于高效低毒的挽救性方案.
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