5-氨基酮戊酸光动力治疗表浅基底细胞癌患者的疗效研究

摘要

Objective To investigate the efficacy of 5-Aminolevulinic acid and photodynamic therapy ( ALA-PDT) for superficial basal cell carcinoma ( BCC) .Methods 65 cases of BCC patients were randomly divided into the experiment group (33 cases) and the control group (32 cases).All patients received ALA-PDT treatment and patients in the experiment group were given additional imiquimod.The efficacy,cosmetic result and adverse reactions were followed-up.Results Complete remis-sion rate and partial remission rate in the experiment group were higher than those of the control group,there had significant differ-ence (P<0.05);total remission rate in the control group was higher than that of the experiment group,but there had no signifi-cant difference (P>0.05).During 1-year follow-up visit,the recurrence rate in the control group and the experiment group were 15.63%,and 6.06%,respectively,there had significant difference (P<0.05).The rate of excellence,good,and well in cosmetic results in the experiment group was higher than those of the control group,there had significant difference (P<0.05).Conclu-sion ALA-PDT combined with imiquimod for BCC is effective with good cosmetic result.It is a safe option and it is worthy of clinical application.%目的：探讨5-氨基酮戊酸（ALA）光动力疗法（PDT）治疗表浅基底细胞癌（BCC）患者的疗效。方法选取BCC患者65例，随机分为试验组（33例）和对照组（32例），两组患者均行ALA-PDT治疗，试验组在此基础上联合咪喹莫特治疗。对患者的治疗效果、美容效果和不良反应等跟踪随访记录。结果 ALA-PDT联合咪喹莫特治疗BCC后完全缓解率和部分缓解率显著高于对照组（P＜0．05），而总有效率高于试验组，但差异无显著性（P＞0．05）。随访1年后，对照组复发5例（15．63％），试验组2例复发（6．06％），试验组患者复发率显著低于对照组（P＜0．05）。试验组美容效果优秀、良好及良好以上比例显著高于对照组（P＜0．05），美容效果差比例显著低于对照组（P＜0．05）。两组均未出现重度不良反应。结论 ALA-PDT联合咪喹莫特作为治疗BCC一种新治疗技术，兼顾了疗效和美容的效果，且疗效显著，安全有效，值得临床推荐。