5－氨基酮戊酸光动力疗法联合重组人干扰素α2b 软膏治疗老年患者表浅基底细胞癌的临床观察

摘要

Objective To evaluate the therapeutic effect of 5-aminolevulinic acid mediated photody-namic therapy(ALA-PDT)in combination with recombinant human interferon alpha 2b ointment on superficial basal cell carcinoma(BCC)in elderly.Methods A total of 143 elderly patients with superficial BCC was ran-domly divided into PDT group(n=72 cases)and the surgical group(n=71 cases).The patients in the two groups were given the ALA-PDT in combination with IFN-α2b and routine surgical treatment respectively .The effica-cy after treatment was observed according to surgical wound area , lesion area , recurrence and security during 1 year follow-up.Results The results displayed the complete remission rate of lesion in the PDT group was sig-nificantly higher than that in the surgical group (81.94%vs.57.75%,P<0.05)after treatment,and the total ef-fective rate of BCC was also higher than that in the surgical group ,but no significant difference was identified in the two groups(91.66%vs.81.73%,P>0.05).During 1 year follow-up after treatment,the results showed the rate of recurrence in the PDT group was significantly lower than that in the surgical group (9.72% vs.22. 54%,P<0.05).Moreover,the mean wound area,the lesion area in the PDT group after treatment were also sig-nificantly smaller than that in the surgical group (P<0.05).Conclusion ALA-PDT in combination with IFN is an effective method with lower recurrence and minor trauma in the treatment of superficial basal cell carcino -ma.%目的：探讨5－氨基酮戊酸光动力疗法（5－Aminolevulinic acid mediated photodynamic thera-py，ALA－PDT）联合重组人干扰素α2b软膏治疗老年表浅基底细胞癌（Basal cell carcinoma，BCC）患者的疗效。方法选取143例BCC老年患者，随机分为PDT组（72例）和手术组（71例），PDT组采用ALA－PDT疗法联合干扰素治疗，手术组采取常规外科手术治疗，对两组患者的疗效、手术创伤面积、病变面积、复发情况、安全性等进行随访比较。结果 PDT 组治疗后完全缓解率显著高于手术组（81．94％ vs．57．75％，P＜0．05），而两组总有效率比较无统计学差异（91．66％ vs．81．73％，P＞0．05）；随访1年后， PDT组患者复发率显著低于手术组（9．72％vs．22．54％，P＜0．05）；此外，PDT组平均创伤面积、治疗后病变面积也显著小于手术组（ P＜0．05）。结论 ALA－PDT联合干扰素是一种临床疗效好，复发率低，创伤性小的治疗表浅基底细胞癌的有效方法。