PEG化隐形纳米脂质体的研究进展

摘要

PEG化隐形纳米脂质体作为一种新型药物栽体,由于其特殊的体内作用特点,和普通脂质体相比具有长效、靶向、高效、低毒等优点,已在靶向制剂、控释制剂等领域中得到广泛应用.本文重点围绕PEG化隐形纳米脂质体的药动学、组织分布、提高肿瘤靶向性、降低药物毒性等方面对其近年来在药物转运系统中的研究与应用做一综述.%PEGylation stealth nano-liposomes as a novel drug delivery carrier has the advantages of long-term, targeting, high efficiency and low toxicily, compared with conventional liposomes, and has been widely applied in targeting preparations, modified-release preparations, etc. The applications of PEGylation stealth nano-liposomes including pharmacokinetics. tissue distribution. reducing toxicity and enhancing tumor targeting were reviewed in this paper.