Eleven compounds were isolated from the South China Sea gorgonian Muricella flexuosa by meanings of silica gel,Sephadex LH-20 column chromatography and recrystallization. Their structures were identified by physicochemical properties, spectroscopic analysis and comparison with the data of literatures. These 11 compounds were caffeine (1), 1, 7-diethylhypoxnathine (2), 1-methylhypoxnathine (3), 7,9-dimethy-6-( N-methyl) purine-8-one (4), 7-ethyladenine (5), l,7-diethylpurine-6,8-dione (6) .uracil (7) .thymine (8), 2'-deoxyuridine (9), 2'-deoxythymidine (10), 3-eth-yl-2'-deoxythymidine (11). Compounds 2-6 and 11 were obtained from the genus Muricella for the first time,and 4 and 11 were isolated from nature for the first time.%对采自海南三亚的中华小尖柳珊瑚Muricella flexuosa的化学成分进行研究,采用反复硅胶柱色谱法、Sephadex LH-20柱色谱法及重结晶等手段对化合物进行分离和纯化,通过理化性质及光谱分析并结合文献对照,鉴定得到11个嘌呤、嘧啶类化合物:咖啡碱(1),1,7-二甲基次黄嘌呤(2),1-甲基次黄嘌呤(3),7,9-二甲基-6-氮甲基嘌呤-8-酮(4),7-甲基腺嘌呤(5),1,7-二甲基嘌呤-6,8-二酮(6),尿嘧啶(7),胸腺嘧啶(8),2′-脱氧尿嘧啶核苷(9),2′-脱氧胸腺嘧啶核苷(10),3-乙基-2′-脱氧尿嘧啶核苷(11).其中化合物2~6,11为首次从该属中分离得到,化合物4和11为新的天然产物.
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