南海小月柳珊瑚中倍半萜类化学成分研究

摘要

To investigate the chemical constituents of a South China Sea gorgonian Menella sp.,the isolation of ingredients was performed by solvent extraction and repeated chromatography on silica gel,Sephadex LH-20 and preparative TLC.The structures of isolated compounds were determined by spectroscopic analysis and comparison of 1H and 13C NMR data with those reported in literatures.Three subergorane sesquiterpenoids and one suberosane sesquiterpenoid were isolated.Their structures were identified as subergorgic acid (1),subergorgic acid methyl ester (2),2β-hydroxyl subergorgic acid methyl ester (3),and suberosenol A (4).All compounds were isolated from the genus Menella for the first time.%对南海小月柳珊瑚Menella sp.的化学成分进行研究.应用反复硅胶柱层析、Sephadex LH-20柱色谱和制备薄层等多种色谱方法进行分离和纯化.从中分离得到3个subergorane倍半萜和1个suberosane倍半萜化合物,利用波谱分析技术和文献比对等方法确定化合物的结构,分别为柳珊瑚酸(1),柳珊瑚酸甲酯(2),2β-羟基柳珊瑚酸甲酯(3)和suberosenolA(4).以上化合物均为首次从小月柳珊瑚属(Menella)中分离得到.