正交试验优选联苯肼酯γ-环糊精的包合工艺

摘要

The optimum inclusion process conditions for bifenzate usingγ-cyclodextrin were studied. The inclusion technology was optimized by orthogonal test with the mole ratio ofγ-cyclodextrin to bifenzate, inclusion time, inclusion temperature as factors and with the yield and the inclusion rate as indexes for evaluation. The optimum inclusion conditions were established as the follow:n(γ-cyclodextrin)∶n(bifenazate)=1∶1, the inclusion temperature at 30℃ for 5 h. The technology was effective with high yield and inclusion rate.%研究γ-环糊精包合联苯肼酯的制备工艺。以γ-环糊精与联苯肼酯的物质的量之比、包合时间、包合温度为考察因素，以包合物收率和联苯肼酯包合率的综合评分为评价指标，采用正交试验优选工艺，确定最佳包合工艺条件为n(γ-环糊精)∶n(联苯肼酯)＝1∶1，搅拌时间为5 h，包合温度为30℃。该工艺联苯肼酯包合率及包合物收率较高，包合效果良好。