线粒体功能障碍与动脉粥样硬化及其危险因素

摘要

动脉粥样硬化(AS)严重威胁着人类的健康,其发病机制较为复杂.近年来,有关线粒体功能障碍与AS关系的研究日益增多.因活性氧簇产生过量而引发的线粒体氧化损伤,尤其是线粒体DNA损伤所导致的线粒体功能障碍在AS发生及其相关危险因素(如高血脂、高血压、吸烟、年龄、糖尿病、肥胖、高同型半胱氨酸血症)中起关键作用.现就线粒体功能障碍与AS形成之间的关系进行综述.%Atherosclerosis( AS ) seriously threatens to human health, the pathogenesis of which is complicated. Recently,there are more research focusing on the relationship between mitochondrial dysfunction and pathogenesis of AS. An excess of reactive oxygen species inducing mitochondrial oxidative damage, especially the mitochondrion DNA damage which leads to mitochondrial dysfunction, plays a key role in the pathogenesis of AS and related risk factors, such as hyperlipemia, hypertension, smoking, age, diabetes, obesity and hyperhomocysteinemia. Here is to review on the correlation of mitochondrial dysfunction and the pathogenesis of AS.