首页> 外国专利> compost and respective process and manufacture, pharmaceutical and fatty acid compositions, uses of compost and methods of controlling body weight reduction and / or preventing body weight gain, treating and / or preventing obesity or an overweight condition , diabetes, amyloidosis-related diseases, treatment or prophylaxis of multiple risk factors for cardiovascular diseases and prevention of stroke, cerebral ischemic attacks or passengers related to atherosclerosis of various arteries

compost and respective process and manufacture, pharmaceutical and fatty acid compositions, uses of compost and methods of controlling body weight reduction and / or preventing body weight gain, treating and / or preventing obesity or an overweight condition , diabetes, amyloidosis-related diseases, treatment or prophylaxis of multiple risk factors for cardiovascular diseases and prevention of stroke, cerebral ischemic attacks or passengers related to atherosclerosis of various arteries

机译:堆肥及其各自的工艺和制造,药物和脂肪酸组合物,堆肥的用途以及控制体重减轻和/或预防体重增加,治疗和/或预防肥胖或超重的疾病,糖尿病,淀粉样变性病相关疾病,治疗的方法或预防多种心血管疾病危险因素,并预防中风,脑缺血发作或与各种动脉粥样硬化有关的乘客

摘要

COMPOSITE AND RESPECTIVE MANUFACTURING PROCESS, PHARMACEUTICAL AND FATTY ACID COMPOSITIONS, COMPOUND USES AND METHODS FOR THE CONTROL OF BODY WEIGHT REDUCTION AND / OR PREVENTION OF BODY WEIGHT, TREATMENT AND / OR TREATMENT AND / OR TREATMENT AND / OR TREATMENT AND / OR TREATMENT OR / OR TREATMENT AND / OR PROTECTION , DIABETES, AMILOIDOSIS-RELATED DISEASES, TREATMENT OR PROPHYLAXIS OF MISCELLANEOUS RISK FACTORS FOR CARDIOVASCULAR DISEASES AND THE PRESENCE OF CEREBRAL EXCHANGE, ISCHEMIC CEREBRAISAL ATTACKS ARE ANOTHER HAIR-RELATED HAIR COMBINATION CONTAINER THERAPEUTIC COMBINATIONS. I); where -R ~ 1 ~ and R ~ 2 ~ are the same or different and can be selected from the group consisting of a hydrogen atom, a hydroxy group, an akilm group, a halogen atom, an alkoxy group, a group acyloxy, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alksulfinyl group, an alkylsulfonyl group, an amino group and an alkylamino group; and -X represents a carboxylic acid group, a carborxylate group or a carboxamide group; or any pharmaceutically acceptable salt, solvate, complex or prodrug thereof, with the proviso that the compound of formula (I) is not acid (all-Z) -4,7,10,13,16,19-docosahexaenoic (DHA), alpha-menthyl DHA, methyl alpha-methyl DHA ester, ethyl methyl alpha DHA ester or ethyl alpha hydroxy ester DHA. A fatty acid composition and a pharmaceutical composition comprising these compounds are also disclosed. The use of these compounds as medicines is also revealed, in particular for the treatment of type 2 diabetes.
机译:控制身体重量减少和/或预防,控制和/或治疗和/或治疗和/或治疗和/或治疗和/或治疗或/和/或控制的复合和相应的制造过程,药物和脂肪酸组成,化合物的使用和方法或治疗和/或保护,糖尿病,与阿米洛病有关的疾病,对心血管疾病的其他危险因素的治疗或预防,以及脑置换,缺血性脑脊液发作的发生是另一个与头发有关的。一世);其中-R〜1〜和R〜2〜相同或不同,并且可以选自氢原子,羟基,烷基,卤素原子,烷氧基,酰氧基,酰基,烯基,炔基,芳基,烷硫基,烷氧羰基,链亚磺酰基,烷基磺酰基,氨基和烷基氨基; -X表示羧酸基,碳硼酸酯基或羧酰胺基。或其任何药学上可接受的盐,溶剂化物,复合物或前药,条件是式(I)的化合物不是酸(all-Z)-4,7,10,13,16,19-二十二碳六烯酸(DHA), α-薄荷基DHA,甲基α-甲基DHA酯,乙基甲基αDHA酯或乙基α羟基酯DHA。还公开了包含这些化合物的脂肪酸组合物和药物组合物。还揭示了这些化合物作为药物的用途,特别是用于治疗2型糖尿病。

著录项

  • 公开/公告号BRPI0611159A2

    专利类型

  • 公开/公告日2012-07-31

    原文格式PDF

  • 申请/专利权人 PRONOVA BIOPHARMA NORGE AS;

    申请/专利号BR2006PI11159

  • 申请日2006-05-04

  • 分类号C11C3;A61K31/202;A61K31/232;A61K31/421;A61P3/04;A61P3/10;A61P9/10;C07C57/03;C07C69/587;C07D263/24;

  • 国家 BR

  • 入库时间 2022-08-21 17:25:30

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