TGF-β与PD-L1在肿瘤微环境中的相互调节作用

摘要

Transforming growth factors-β (TGF-β) is a class of cytokines possessing many kinds of biologic activity,including the regulation of cell proliferation,differentiation,development,and apoptosis.TGF-β plays a dual regulatory function in the development of tumor.Costimulatory molecule programmed death ligand 1 (PD-L1) is widely expressed in tumor issues, which inhibits T cell immune function to promote tumor development.The mutual regulation of TGF-β and PD-L1 in tumor microenvironment is very important for the occurrence and development of tumor.This paper will review the mutual regulation of TGF-β and PD-L1 in tumor microenvironment.%转化生长因子β(TGF-β)是一类具有多种生物学活性的细胞因子,参与调节细胞的增殖、分化、发育和凋亡等多种生命活动,在肿瘤的发生、发展中起到双重调节作用.协同刺激分子程序性死亡配体1(PD-L1)广泛表达于肿瘤组织,具有抑制T细胞免疫从而促进肿瘤发生的作用.肿瘤微环境中TGF-β和PD-L1之间的相互调节作用对肿瘤的发生、发展尤为重要.现就TGF-β和PD-L1在肿瘤微环境中的相互调节作用予以综述.